|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin (1-15) [GAL(1-15)] participates in mood regulation and depression.
|
31128121 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results may provide a basis for the development of novel therapeutic strategies using galanin N-terminal fragment (1-15) analogues for the treatment of depression and reward-related diseases.
|
31081442 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the SNP rs948854 in the GAL gene seems to be involved in the modulation of depressive state, especially in individuals with GG genotype.
|
28987550 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
A role of galanin in depression is also supported by a recent candidate gene study, showing that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
|
30627087 |
2018 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Galanin, a peptide expressed in mammalian brain regions, has been implicated in anxiety and depression.
|
29499176 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin (GAL), an estrogen-inducible neuropeptide has also been reported to be associated with depression.
|
30487761 |
2018 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL<sub>1</sub>-GAL<sub>2</sub>-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
|
28196617 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results open up the possibility to use GAL(1-15) as for a combination therapy with FLX as a novel strategy for treatment of depression.
|
28288814 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin and its receptors appear to play key roles in depression-like behavior, and effects on hippocampal neurogenesis are relevant to pharmacological strategies for treating depression, which in part appear to rely on restoring altered neurogenesis.
|
28431685 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Correcting abnormal galanin function in depression could prove to be a novel target for drug development.
|
24706871 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
There is a large body of pre-clinical and some clinical data to link the neuropeptide galanin to a range of physiological and pathological functions that include metabolism, depression, and addiction.
|
25228436 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Correcting abnormal galanin function in depression could prove to be a novel target for drug development.
|
24706871 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In recent years, numerous studies of animal models have suggested an involvement of GAL and GAL1 and GAL2 receptors in anxiety- and depression-related behavior.
|
24782539 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
GAL(1-15) induced strong depression-like and anxiogenic-like effects in all the tests.
|
25522404 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
These results demonstrate the beneficial effects of exercise in a rodent model of epilepsy and depression comorbidity and suggest a potential role for galanin.
|
23933912 |
2013 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The findings clearly indicate that the GAL gene polymorphism is closely correlated to the incidence of depression in the Chinese Han female patients.
|
23741354 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment.
|
20237460 |
2010 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intracerebroventricular injection of galanin has been shown to modulate depression and anxiety-like behaviors in the rat.
|
18554714 |
2008 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The neuropeptide galanin is widely expressed in the periphery and the central nervous system and mediates diverse physiological processes and behaviors including alcohol abuse, depression and anxiety.
|
17083333 |
2007 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both pharmacological and genetic studies suggest a role for galanin in depression-like behaviour in rodent models.
|
16863269 |
2006 |