GAL, galanin and GMAP prepropeptide, 51083

N. diseases: 226; N. variants: 3
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 AlteredExpression disease BEFREE Thus, GAL and its receptor GALR3 are differentially methylated and expressed in brains of MDD subjects in a region- and sex-specific manner. 27940914 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease CTD_human Thus, GAL and its receptor GALR3 are differentially methylated and expressed in brains of MDD subjects in a region- and sex-specific manner. 27940914 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease BEFREE Association of galanin and major depressive disorder in the Chinese Han population. 23741354 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). 21042317 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease BEFREE The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment. 20237460 2010