GAL, galanin and GMAP prepropeptide, 51083

N. diseases: 226; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4225318
Disease: EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
0.600 GeneticVariation disease UNIPROT Galanin pathogenic mutations in temporal lobe epilepsy. 25691535 2015
CUI: C4225318
Disease: EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
0.600 Biomarker disease GENOMICS_ENGLAND Galanin pathogenic mutations in temporal lobe epilepsy. 25691535 2015
CUI: C4225318
Disease: EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
0.600 Biomarker disease CTD_human
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.510 Biomarker group BEFREE Low galanin levels were one of characters of obese patients with high blood pressure, and this levels may be taken as a novel biomarker to predict the development of high blood pressure in obese patients. 27538957 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.510 Biomarker group RGD Data suggest that alpha CGRP and GAL may participate in the mechanisms involved in the establishment/maintenance of hypertension induced by aortic coarctation. 15275958 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.510 Biomarker group CTD_human Galanin/alpha2-receptor interactions in central cardiovascular control. 10818254 2000
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Galanin (1-15) [GAL(1-15)] participates in mood regulation and depression. 31128121 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE These results may provide a basis for the development of novel therapeutic strategies using galanin N-terminal fragment (1-15) analogues for the treatment of depression and reward-related diseases. 31081442 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE These results may provide a basis for the development of novel therapeutic strategies using galanin N-terminal fragment (1-15) analogues for the treatment of depression and reward-related diseases. 31081442 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Galanin (1-15) [GAL(1-15)] participates in mood regulation and depression. 31128121 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE In conclusion, the SNP rs948854 in the GAL gene seems to be involved in the modulation of depressive state, especially in individuals with GG genotype. 28987550 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE A role of galanin in depression is also supported by a recent candidate gene study, showing that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. 30627087 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Galanin, a peptide expressed in mammalian brain regions, has been implicated in anxiety and depression. 29499176 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Galanin (GAL), an estrogen-inducible neuropeptide has also been reported to be associated with depression. 30487761 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE A role of galanin in depression is also supported by a recent candidate gene study, showing that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. 30627087 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Galanin (GAL), an estrogen-inducible neuropeptide has also been reported to be associated with depression. 30487761 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 AlteredExpression disease BEFREE Galanin, a peptide expressed in mammalian brain regions, has been implicated in anxiety and depression. 29499176 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL<sub>1</sub>-GAL<sub>2</sub>-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression. 28196617 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE The results open up the possibility to use GAL(1-15) as for a combination therapy with FLX as a novel strategy for treatment of depression. 28288814 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Galanin and its receptors appear to play key roles in depression-like behavior, and effects on hippocampal neurogenesis are relevant to pharmacological strategies for treating depression, which in part appear to rely on restoring altered neurogenesis. 28431685 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 AlteredExpression disease BEFREE Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL<sub>1</sub>-GAL<sub>2</sub>-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression. 28196617 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Galanin and its receptors appear to play key roles in depression-like behavior, and effects on hippocampal neurogenesis are relevant to pharmacological strategies for treating depression, which in part appear to rely on restoring altered neurogenesis. 28431685 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE The results open up the possibility to use GAL(1-15) as for a combination therapy with FLX as a novel strategy for treatment of depression. 28288814 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET Correcting abnormal galanin function in depression could prove to be a novel target for drug development. 24706871 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET There is a large body of pre-clinical and some clinical data to link the neuropeptide galanin to a range of physiological and pathological functions that include metabolism, depression, and addiction. 25228436 2014