EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Galanin pathogenic mutations in temporal lobe epilepsy.
|
25691535 |
2015 |
EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Galanin pathogenic mutations in temporal lobe epilepsy.
|
25691535 |
2015 |
EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
Hypertensive disease
|
0.510 |
Biomarker
|
group |
BEFREE |
Low galanin levels were one of characters of obese patients with high blood pressure, and this levels may be taken as a novel biomarker to predict the development of high blood pressure in obese patients.
|
27538957 |
2017 |
Hypertensive disease
|
0.510 |
Biomarker
|
group |
RGD |
Data suggest that alpha CGRP and GAL may participate in the mechanisms involved in the establishment/maintenance of hypertension induced by aortic coarctation.
|
15275958 |
2004 |
Hypertensive disease
|
0.510 |
Biomarker
|
group |
CTD_human |
Galanin/alpha2-receptor interactions in central cardiovascular control.
|
10818254 |
2000 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin (1-15) [GAL(1-15)] participates in mood regulation and depression.
|
31128121 |
2019 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results may provide a basis for the development of novel therapeutic strategies using galanin N-terminal fragment (1-15) analogues for the treatment of depression and reward-related diseases.
|
31081442 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results may provide a basis for the development of novel therapeutic strategies using galanin N-terminal fragment (1-15) analogues for the treatment of depression and reward-related diseases.
|
31081442 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin (1-15) [GAL(1-15)] participates in mood regulation and depression.
|
31128121 |
2019 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the SNP rs948854 in the GAL gene seems to be involved in the modulation of depressive state, especially in individuals with GG genotype.
|
28987550 |
2018 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
A role of galanin in depression is also supported by a recent candidate gene study, showing that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
|
30627087 |
2018 |
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Galanin, a peptide expressed in mammalian brain regions, has been implicated in anxiety and depression.
|
29499176 |
2018 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin (GAL), an estrogen-inducible neuropeptide has also been reported to be associated with depression.
|
30487761 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A role of galanin in depression is also supported by a recent candidate gene study, showing that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
|
30627087 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin (GAL), an estrogen-inducible neuropeptide has also been reported to be associated with depression.
|
30487761 |
2018 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Galanin, a peptide expressed in mammalian brain regions, has been implicated in anxiety and depression.
|
29499176 |
2018 |
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL<sub>1</sub>-GAL<sub>2</sub>-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
|
28196617 |
2017 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results open up the possibility to use GAL(1-15) as for a combination therapy with FLX as a novel strategy for treatment of depression.
|
28288814 |
2017 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin and its receptors appear to play key roles in depression-like behavior, and effects on hippocampal neurogenesis are relevant to pharmacological strategies for treating depression, which in part appear to rely on restoring altered neurogenesis.
|
28431685 |
2017 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL<sub>1</sub>-GAL<sub>2</sub>-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
|
28196617 |
2017 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Galanin and its receptors appear to play key roles in depression-like behavior, and effects on hippocampal neurogenesis are relevant to pharmacological strategies for treating depression, which in part appear to rely on restoring altered neurogenesis.
|
28431685 |
2017 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results open up the possibility to use GAL(1-15) as for a combination therapy with FLX as a novel strategy for treatment of depression.
|
28288814 |
2017 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Correcting abnormal galanin function in depression could prove to be a novel target for drug development.
|
24706871 |
2014 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
There is a large body of pre-clinical and some clinical data to link the neuropeptide galanin to a range of physiological and pathological functions that include metabolism, depression, and addiction.
|
25228436 |
2014 |