|
Spina Bifida
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Previous study has shown that PCMT1 polymorphisms rs4552 and rs4816 of infant are associated with spina bifida in the Californian population.
|
22647835 |
2012 |
|
Spina Bifida
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that the Ile120Val polymorphism of PCMT1 gene is a genetic modifier for the risk of spina bifida.
|
16256389 |
2006 |
|
Epilepsy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Pcmt1 knock-out mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure.
|
28100787 |
2017 |
|
Epilepsy
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Mice with a knockout of the gene (Pcmt1) for this enzyme (KO, -/-) exhibit a pronounced neuropathology with fatal epileptic seizures at 30-60 days.
|
25465735 |
2015 |
|
Epilepsy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure.
|
29856810 |
2018 |
|
Epileptic Seizures
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Mice with a knockout of the gene (Pcmt1) for this enzyme (KO, -/-) exhibit a pronounced neuropathology with fatal epileptic seizures at 30-60 days.
|
25465735 |
2015 |
|
Epileptic Seizures
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure.
|
29856810 |
2018 |
|
Epileptic Seizures
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Pcmt1 knock-out mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure.
|
28100787 |
2017 |
|
Neural Tube Defects
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We hypothesized that a known functional polymorphism (Ile120Val) in the human PCMT1 gene is associated with an increased risk of folate-responsive human NTDs.
|
16256389 |
2006 |
|
Neural Tube Defects
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Maternal PCMT1 gene polymorphisms and the risk of neural tube defects in a Chinese population of Lvliang high-risk area.
|
22647835 |
2012 |
|
Anencephaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although the significance was lost after multiple comparison correction, the results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in this Chinese population.
|
22647835 |
2012 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Survival analysis showed that PCMT1 protein high-expression was an independent unfavorable prognostic factor for bladder cancer patients.
|
29517839 |
2018 |
|
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Survival analysis showed that PCMT1 protein high-expression was an independent unfavorable prognostic factor for bladder cancer patients.
|
29517839 |
2018 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The role of protein l-isoaspartate (d-aspartate) O-methyltransferase (PCMT1) in human cancer was generally cognized.
|
29517839 |
2018 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results support a role for post-translational modifications and PIMT in the development of type 1 diabetes in the diabetes-prone BB rat, and perhaps also in humans.
|
17216280 |
2007 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
The results support a role for post-translational modifications and PIMT in the development of type 1 diabetes in the diabetes-prone BB rat, and perhaps also in humans.
|
17216280 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to assess the role of PIMT in the development of type 1 diabetes.
|
17216280 |
2007 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, cumulative evidence suggests that PIMT functions in cardiac energy metabolism by interacting with nuclear receptor coactivators and this property could be useful in the management of heart failure.
|
29772707 |
2018 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, cumulative evidence suggests that PIMT functions in cardiac energy metabolism by interacting with nuclear receptor coactivators and this property could be useful in the management of heart failure.
|
29772707 |
2018 |
|
Premature Menopause
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that four polymorphisms in the protein L-isoaspartyl-O-methyltransferase (PCMT1) gene, encoding a protein repair enzyme, are associated with premature ovarian failure (POF).
|
18582870 |
2009 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
PCMT1 protein expression was obviously correlated with clinical stage, muscularis invasion, lymph node metastasis, and distant metastasis.
|
29517839 |
2018 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that PIMT was downregulated at both gene and protein levels by DA-induced oxidative stresses in SH-SY5Y neuroblastoma cells.
|
25800307 |
2015 |
|
Parkinson Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This suggests that ROS generated from cytosolic dopamine could reduce both the PCMT1 gene promoter activity and the PIMT protein level thus decreasing its capacity to repair proteins involved in apoptosis and could contribute to neuronal cell death observed in PD.
|
24631677 |
2014 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aims to explore the potential role of PCMT1 in reducing MST1-induced neuronal apoptosis after subarachnoid hemorrhage (SAH) in rats.
|
28534197 |
2017 |
|
Ovarian Failure, Premature
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that four polymorphisms in the protein L-isoaspartyl-O-methyltransferase (PCMT1) gene, encoding a protein repair enzyme, are associated with premature ovarian failure (POF).
|
18582870 |
2009 |