PCNA, proliferating cell nuclear antigen, 5111

N. diseases: 581; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
0.600 GermlineCausalMutation disease ORPHANET Hypomorphic PCNA mutation underlies a human DNA repair disorder. 24911150 2014
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
0.600 GeneticVariation disease UNIPROT Hypomorphic PCNA mutation underlies a human DNA repair disorder. 24911150 2014
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
0.600 CausalMutation disease CLINVAR
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.510 Biomarker disease CTD_human On the individual data for both TGF-alpha and PCNA, most of the HBs showed higher positive rates than HCCs. 11560253 2002
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.510 AlteredExpression disease BEFREE To evaluate Bcl-xL, Bax, PCNA, cytokeratin 19 (CK-19), glycogen content and DNA ploidy expression in hepatoblastoma (HB) and their prognostic value. 20803149 2010
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.510 Therapeutic disease RGD Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma. 23219601 2013
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker disease BEFREE The tumor's cellularity, the Ki-67 positivity rate and PCNA, together with the clinical stage and the histological differentiation bring extra pieces of useful information in order to anticipate the evolution and the prognosis of lung cancer. 29940632 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 AlteredExpression disease BEFREE Expression of proliferating cell nuclear antigen in lung cancer: a systematic study and correlation with DNA ploidy. 1351473 1992
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 AlteredExpression disease BEFREE Cyclin E expression negatively affects lung cancer prognosis. 17360482 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker disease BEFREE Cyclin E-driven transgenic lung cancers expressed a gene profile implicating HH pathway activation. 22923130 2012
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker disease CTD_human Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 11884234 2002
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker disease BEFREE These data suggest that targeting PCNA with PCNA-I1S may provide a novel approach for enhancing the efficacy of chemotherapy and radiation therapy in treatment of human prostate and lung cancer. 31600334 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 AlteredExpression disease BEFREE Overexpression of TIM-4 promoted lung cancer cell growth and proliferation, and upregulated the expression of PCNA, cyclin A, cyclin B1 and cyclin D1, accompanied by accumulation of lung cancer cells in S phase. 26512878 2015
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker disease BEFREE Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention. 21149327 2010
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker disease BEFREE Thus, our results unraveled a novel regulatory of GSK3β by PCNA and provided a promising direction for treatment of lung cancer. 31607135 2020
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation disease BEFREE To examine the role of elevated glucose uptake in lung cancer, we performed PCR amplification of 2 facilitative glucose transporter genes (GLUT1 and GLUT3) and immunohistochemical staining for GLUT1, proliferating cell nuclear antigen (PCNA), and sialyl Lewis x (sLe(x)) on tumor specimens from 327 patients with lung cancer who underwent surgical resection from 1980 to 1993. 9133454 1997
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker disease BEFREE Prognostic role of cyclin D1 in lung cancer. Relationship to proliferating cell nuclear antigen. 10101007 1999
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 AlteredExpression disease BEFREE The reverse transcription quantitative polymerase chain reaction analysis revealed that PCNA‑1 was significantly upregulated (up to 5‑fold) in the lung cancer cells (P<0.05), and the overexpression of miR‑204 caused the downregulation of PCNA‑1 in A549 lung cancer cells. 30628638 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation disease BEFREE Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men. 24012694 2013
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 AlteredExpression disease BEFREE Our study suggests that YB-1 expression correlates with Topo IIalpha and PCNA expression in lung cancer. 11724293 2001
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker disease BEFREE Meanwhile, the combination suppressed PCNA and NF-κB pathway in 4 kinds of lung cancer cells. 29608021 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker disease BEFREE We further showed that the colon cancer cell line expressing the wild-type APC gene was more sensitive to a DNA-methylating agent due to decreased DNA repair by long patch BER than the cell line expressing the mutant APC gene lacking the proliferating cell nuclear antigen-interacting protein-like box. 15548520 2005
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker disease BEFREE In our research, we used transcriptional methods and immunohistochemistry to investigate the LGR5 gene and protein expression, examined proliferating cell nuclear antigen(PCNA) and Ki67 which were the classic markers for cell proliferation in LGR5 protein positive and negative colon cancer among mice model and patients. 24063790 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 AlteredExpression disease BEFREE This effect was accompanied by pro-apoptosis of C086 in colon cancer cells and lower expression of PCNA in C086 treated colon cancer xenografts. 21900746 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker disease CTD_human 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats. 19723570 2009