ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
Hypomorphic PCNA mutation underlies a human DNA repair disorder.
|
24911150 |
2014 |
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Hypomorphic PCNA mutation underlies a human DNA repair disorder.
|
24911150 |
2014 |
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Hepatoblastoma
|
0.510 |
Biomarker
|
disease |
CTD_human |
On the individual data for both TGF-alpha and PCNA, most of the HBs showed higher positive rates than HCCs.
|
11560253 |
2002 |
Hepatoblastoma
|
0.510 |
AlteredExpression
|
disease |
BEFREE |
To evaluate Bcl-xL, Bax, PCNA, cytokeratin 19 (CK-19), glycogen content and DNA ploidy expression in hepatoblastoma (HB) and their prognostic value.
|
20803149 |
2010 |
Hepatoblastoma
|
0.510 |
Therapeutic
|
disease |
RGD |
Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma.
|
23219601 |
2013 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
The tumor's cellularity, the Ki-67 positivity rate and PCNA, together with the clinical stage and the histological differentiation bring extra pieces of useful information in order to anticipate the evolution and the prognosis of lung cancer.
|
29940632 |
2018 |
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of proliferating cell nuclear antigen in lung cancer: a systematic study and correlation with DNA ploidy.
|
1351473 |
1992 |
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin E expression negatively affects lung cancer prognosis.
|
17360482 |
2007 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin E-driven transgenic lung cancers expressed a gene profile implicating HH pathway activation.
|
22923130 |
2012 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
CTD_human |
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
|
11884234 |
2002 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that targeting PCNA with PCNA-I1S may provide a novel approach for enhancing the efficacy of chemotherapy and radiation therapy in treatment of human prostate and lung cancer.
|
31600334 |
2019 |
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of TIM-4 promoted lung cancer cell growth and proliferation, and upregulated the expression of PCNA, cyclin A, cyclin B1 and cyclin D1, accompanied by accumulation of lung cancer cells in S phase.
|
26512878 |
2015 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention.
|
21149327 |
2010 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our results unraveled a novel regulatory of GSK3β by PCNA and provided a promising direction for treatment of lung cancer.
|
31607135 |
2020 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To examine the role of elevated glucose uptake in lung cancer, we performed PCR amplification of 2 facilitative glucose transporter genes (GLUT1 and GLUT3) and immunohistochemical staining for GLUT1, proliferating cell nuclear antigen (PCNA), and sialyl Lewis x (sLe(x)) on tumor specimens from 327 patients with lung cancer who underwent surgical resection from 1980 to 1993.
|
9133454 |
1997 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prognostic role of cyclin D1 in lung cancer. Relationship to proliferating cell nuclear antigen.
|
10101007 |
1999 |
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The reverse transcription quantitative polymerase chain reaction analysis revealed that PCNA‑1 was significantly upregulated (up to 5‑fold) in the lung cancer cells (P<0.05), and the overexpression of miR‑204 caused the downregulation of PCNA‑1 in A549 lung cancer cells.
|
30628638 |
2019 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men.
|
24012694 |
2013 |
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that YB-1 expression correlates with Topo IIalpha and PCNA expression in lung cancer.
|
11724293 |
2001 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Meanwhile, the combination suppressed PCNA and NF-κB pathway in 4 kinds of lung cancer cells.
|
29608021 |
2018 |
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
BEFREE |
We further showed that the colon cancer cell line expressing the wild-type APC gene was more sensitive to a DNA-methylating agent due to decreased DNA repair by long patch BER than the cell line expressing the mutant APC gene lacking the proliferating cell nuclear antigen-interacting protein-like box.
|
15548520 |
2005 |
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
BEFREE |
In our research, we used transcriptional methods and immunohistochemistry to investigate the LGR5 gene and protein expression, examined proliferating cell nuclear antigen(PCNA) and Ki67 which were the classic markers for cell proliferation in LGR5 protein positive and negative colon cancer among mice model and patients.
|
24063790 |
2014 |
Malignant tumor of colon
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
This effect was accompanied by pro-apoptosis of C086 in colon cancer cells and lower expression of PCNA in C086 treated colon cancer xenografts.
|
21900746 |
2011 |
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
CTD_human |
5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats.
|
19723570 |
2009 |