|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In an attempt to evaluate its prognostic significance and clinicopathologic correlation in patients with hepatocellular carcinoma (HCC), the proliferative activity was studied using immunohistochemical staining with monoclonal antibody to PCNA.
|
7513246 |
1994 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Resected hepatoma tissue was stained immunohistochemically with antibodies for proliferating cell nuclear antigen (also called cyclin), a marker of cell proliferation.
|
7927250 |
1994 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the DNA hypomethylation of the PCNA gene found in hepatocellular carcinoma was not due to cell proliferation, but a possible consequence of cell transformation.
|
8102592 |
1993 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In contrast, there was no correlation between c-myc overexpression, found in 19 out of 40 HCC (47.5%), and histological grading of HCC or PCNA labeling index.
|
8104947 |
1993 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
PCNA messenger RNA (mRNA) levels progressively increased from normals to CAH and to cirrhotic patients, and persisted at a high level in the tumorous and in the nontumorous area of HCC subjects, thus showing that the increase of IGF-II transcripts in CAH and cirrhosis is accompanied by an activation of cell mitosis in these samples.
|
8675143 |
1996 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In double-labelling experiments, PCNA and HDV RNA staining did not co-localize, with the exception of two of three cirrhotic tissues associated with HCC, where the association between the two markers was statistically significant.
|
9097264 |
1997 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Sixty-two HCC samples were recruited for evaluation of Id-1 and proliferating cell nuclear antigen (PCNA) protein expression.
|
12949053 |
2003 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
LHGDN |
The aim of the study was to analyze to what extent the presence of DNA-bound PCNA and p21 correlates with cell proliferation and DNA-repair in hepatocellular carcinoma (HCC).
|
14642618 |
2003 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To determine the relationship between ERRP expression and cell proliferation, we performed double staining for ERRP and proliferating cell nuclear antigen (PCNA) in the same HCC specimens.
|
15205570 |
2004 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
There is a marked loss or absence of p57(kip2) expression and high expression of PCNA in HCC, which are involved in carcinogenesis and development of HCC.
|
15754413 |
2005 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, enhanced expression of NPM in HCC correlated with the level of PCNA (R(2)=0.5639) and with the clinical prognostic parameters such as serum alpha fetal protein level, tumour pathological grading, and liver cirrhosis (P<0.05).
|
17245342 |
2007 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
LHGDN |
PTEN down-regulation or p53 (+) correlated with increased HCC dedifferentiation, advanced pathologic stages and high PCNA labeling index (LI) of tumors (P<0.05).
|
17982625 |
2007 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The expression of NET-1 in HCC tissues was positively correlated with PCNA.
|
18214716 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Among the various types of cell-cycle regulators, p16 and p27 are frequently inactivated in HCC and are considered to be potent tumor suppressors. p16, a G1-specific cell-cycle inhibitor that prevents the association of cyclindependent kinase (CDK) 4 and CDK6 with cyclin D1, is frequently inactivated in HCC via CpG methylation of its promoter region. p16 may be involved in the early steps of hepatocarcinogenesis, since p16 gene methylation has been detected in subsets of pre-neoplastic liver cirrhosis patients. p27, a negative regulator of the G1-S phase transition through inhibition of the kinase activities of Cdk2/cyclin A and Cdk2/cyclin E complexes, is now considered to be an adverse prognostic factor in HCC.
|
18350604 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
In 6 of 12 HCCs and in cell lines, we found three major PCNA acidic forms, corresponding to monomers, probably dimers and trimers, and a basic isoform.
|
18521065 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study analyzed the correlation of aPKC-iota with clinicopathology in hepatocarcinoma and Cyclin E and investigated molecular mechanisms of invasion and metastasis of hepatocellular carcinoma.
|
19101699 |
2009 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, we inhibited DNMT1 using siRNA in the SMMC-7721 HCC cell line and found depletion of DNMT1 suppressed cells growth independent of expression of proliferating cell nuclear antigen (PCNA), even in HCC cell lines where DNMT1 was stably decreased.
|
19399937 |
2009 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our study investigated the effects of YSL on human hepatocellular carcinoma and cyclin, and explored its antitumor mechanism in vitro.
|
19491661 |
2009 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A positive correlation was established between the levels of AIB1 protein and PCNA protein in HCC, suggesting that AIB1 may contribute to HCC cell proliferation.
|
20305690 |
2010 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We also show that RMP depletion induced the G(2) arrest of HCC cells characterized by the decreased expression of Cdk1 and Cyclin B. Tumor formation assays further confirmed the in vivo requirement of RMP during HCC growth.
|
21310960 |
2011 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We established that HCC transition from a moderate to poor stage involved densely connected clusters that comprised of PCNA, XRCC5, XRCC6, PARP1, PRKDC, and WRN.
|
21410269 |
2011 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Integrated gene expression data revealed highest expression of proliferation-related CTGF, c-MYC, and PCNA, and lowest expression of BHMT, DMBT1, DUSP1, GADD45g, and GNMT, in more aggressive rat and human HCC.
|
22434528 |
2012 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The pre-S(2) mutant LHBS-induced pro-oncogenic effects: increased cell proliferation, nuclear/cytoplasmic ratio and proliferating cell nuclear antigen expression, were all greatly ameliorated after SAHA treatments, which suggested SAHA as a promising chemopreventive agent for the pre-S(2) mutant oncoprotein-induced HCC.
|
23172669 |
2013 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the molecular mechanisms by which naringenin inhibited NDEA-induced hepatocellular carcinoma in rats by analysing the expression patterns of proliferating cell nuclear antigen, Bcl-2, NF-κB, VEGF and MMP-2/9.
|
23172681 |
2013 |
|
Liver carcinoma
|
0.300 |
Therapeutic
|
disease |
RGD |
PCNA index decreased from 80 in HCC rats to 32 after boron treatment.In the control group, it was 20.
|
23219601 |
2013 |