PCNA, proliferating cell nuclear antigen, 5111
N. diseases: 581; N. variants: 6
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | Biomarker | phenotype | BEFREE | The hypothesis of earlier reports was that the disruption of the p16/cdk-cyclin/Rb cascade is essential for malignant cervical transformation/carcinogenesis. | 9166931 | 1997 | ||||
|
0.100 | Biomarker | phenotype | BEFREE | Moreover, the frequency of different genetic alterations suggests that several pathways are involved in the genesis of these neoplasias and, in particular, it is very probable that p-53 expression and PCNA indices (increased in normal mucosa and preinvasive lesions) may constitute more important biomarkers for the early steps of laryngeal carcinogenesis. | 8694553 | 1996 | ||||
|
0.100 | Biomarker | phenotype | BEFREE | Cyclin D and oncogenesis. | 8453274 | 1993 | ||||
|
0.100 | Biomarker | phenotype | BEFREE | Proliferating cell nuclear antigen (PCNA), a proliferation marker, epidermal growth factor receptor (EGFR), a glycoprotein that plays a role in tumorigenesis by binding the mitogenic epidermal growth factor, and P-glycoprotein, the mdr gene product, are considered to be of prognostic relevance in different tumor types. | 8095852 | 1993 | ||||
|
0.100 | AlteredExpression | phenotype | BEFREE | These multiple general derangements in cyclin expression in human breast cancer cells provide evidence linking aberrant cyclin expression to tumorigenesis. | 8430082 | 1993 | ||||
|
0.100 | Biomarker | phenotype | BEFREE | The modification of cyclin A expression in a human liver cancer by the insertion of hepatitis B viral DNA into the cyclin A gene, and binding of cyclin A to the oncogenic E1A viral protein in adenovirus-infected cells suggest that the cyclin is implicated in human carcinogenesis. | 8384033 | 1993 |