PCNA, proliferating cell nuclear antigen, 5111

N. diseases: 581; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE In addition, the interaction between circ-SMAD7 and proliferating cell nuclear antigen (PCNA) in glioma was studied by performing qRT-PCR and Western blot assay. 31799673 2019
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE S-phase Specific Downregulation of Human O<sup>6</sup>-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21<sup>cip1</sup> Proteins in Glioma Cells. 29510343 2018
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE In the rat glioma C6 orthotopic model, animal survival, flow cytometry for T cells within tumors, and immunohistochemistry for proliferating cell nuclear antigen (PCNA) and IDO were examined. 29993291 2018
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE DDC showed the highest sensitivity and specificity for glioma grading and was negatively correlated with Ki-67 and proliferating cell nuclear antigen expression. 30210702 2018
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE The serine/threonine-protein kinase PFTAIRE 1 (PFTK1) is a member of the cyclin‑dependent kinase family that is highly expressed in several malignant tumors, including hepatocellular carcinoma, esophageal, breast and gastric cancers, and glioma. 28498444 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE An integrated genomic and functional analysis to elucidate DNA damage signaling factors promoting self-renewal of glioma stem cells (GSCs) identified proliferating cell nuclear antigen (PCNA)-associated factor (<i>PAF</i>) up-regulation in glioblastoma. 29073105 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Cell morphology, the level of DNA synthesis, the migration of cells, protein expression levels of proliferating cell nuclear antigen (PCNA) and the level of DNA oxidation in glioma tumours were investigated. 28562655 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Furthermore, a negative correlation was detected between the protein expression of PER2 and PCNA and EGFR in glioma. 25688509 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE In vitro, after the release of glioma cell lines from serum starvation, the expression of B23 was upregulated, as well as PCNA (Proliferating Cell Nuclear Antigen) and cyclin A. 26343305 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE More importantly, TMEM45A siRNA treatment significantly down-regulated the proteins promoting cell cycles transition (Cyclin D1, CDK4 and PCNA) and cell invasion (MMP-2 and MMP-9), which indicted a possible mechanism underlying its functions on glioma. 26722455 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Overexpression of rHSG displayed a strong effect on suppressing C6 cells proliferation in vitro and growth of glioma in vivo, which suggests the use of rHSG as a possible treatment strategy for glioma. p21Cip1, p27Kip1 and proliferating cell nuclear antigen were found to be involved in the tumor suppression mechanism of rHSG. 25362936 2014
CUI: C0017638
Disease: Glioma
Glioma
0.100 GeneticVariation disease BEFREE The XRCC1 Arg194Trp variant affects the proliferating cell nuclear antigen( PCNA) binding region, which suggests that this mutation may contribute to gliomagenesis and a number of articles have examine the association between XRCC1 Arg194Trp and the susceptibility to glioma.However, the results were conflicting. 25227852 2014
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE We then demonstrate that the Dnmt1 phosphorylations by Akt and/or PKC abrogate the interactions of Dnmt1 with PCNA and UHRF1 in cellular and acellular studies including mass spectrometric analyses and the use of primary cultured patient-derived glioma. 20613874 2010