PCNA, proliferating cell nuclear antigen, 5111

N. diseases: 581; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Furthermore, we validated the expressions of these 3 proteins in neuroblastic tumor spectrum tissues by immunohistochemistry revealed that Msi1 and PCNA exhibited increased expression in NB compared with intermedial ganglioneuroblastoma and benign ganglioneuroma, whereas ID1 levels were reduced in NB. 29794872 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells. 26844271 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE An 8 amino acid peptide sequence derived from proliferating cell nuclear antigen (PCNA) has been shown to effectively kill several breast cancer and neuroblastoma cell lines when added exogenously to cell cultures. 25190177 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE These findings indicate that methyl jasmonate suppresses the growth of cultured human neuroblastoma cells associated with downregulation of proliferating cell nuclear antigen, and induces apoptosis accompanied by downregulation of the X-linked inhibitor of apoptosis protein and survivin, which lays the groundwork for further investigation into the mechanisms of methyl jasmonate-mediated anticancer activities. 18525316 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE The proteins and enzymatic activities that were found to copurify with the NB DNA synthesome include: DNA polymerases alpha , delta , and epsilon , proliferating cell nuclear antigen, replication factor A, replication factor C, topoisomerases I and II, flap endonuclease 1, and DNA ligase I. 16034747 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE We found that PCNA was expressed in NB unfavourable cases, with MYCN amplification and high mitosis-karyorrhexis-index (MKI). 12469176 2003
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE We examined the possible derangement of the p16-CDK/cyclin D-pRb pathway in 40 primary neuroblastomas including 18 samples in the unfavorable stages (C and D) and 22 in the favorable stages (A, B, and Ds) by PCR, reverse transcription-PCR, Western blot, and immunohistochemistry and correlated the results with clinical outcome. 11705866 2001
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE The in situ expression of Bcl-2, Rb, p21, p53 and Bax proteins, as well as the proliferation marker proliferating cell nuclear antigen (PCNA) were examined immunocytochemically in a selection of 38 stage- and outcome-identified NB tumours. 9099968 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Thus, although differentiated neuroblastoma and quiescent fibroblasts cells were essentially nondividing, their extracts were competent for DNA replication using DNA polymerases delta, alpha, and possibly epsilon, with proliferating cell nuclear antigen. 9348340 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Our results suggest that PCNA levels may reflect differences in proliferative activity between neuroblastomas, related to stage of the disease and to N-myc gene copy number. 8093685 1993