|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.
|
30811506 |
2019 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that the KSHV v-cyclin and cellular CDK6 kinase phosphorylate NPM on threonine 199 (Thr199) in de novo and naturally KSHV-infected cells and that NPM is phosphorylated to the same site in primary KS tumors.
|
20333249 |
2010 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Viral K-cyclin derived from Kaposi's sarcoma-associated herpesvirus is homologous with mammalian D-type cyclins.
|
20331971 |
2010 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D family members are cellular protooncogenes, and their viral homologues in the Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus type 8 [HHV-8]) and the closely related Herpesvirus saimiri have been implicated as putative cofactors of viral transformation and pathogenesis.
|
11238594 |
2001 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The production of vascular endothelial growth factor (VEGF) and certain proliferation markers (proliferating cell nuclear antigen and Ki-67) were significantly lower in Kaposi's sarcomas from NAC-treated mice than from control mice.
|
11719447 |
2001 |
|
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
While vCYC (AKS 6 of 6; CKS 3 of 3), vMIP-I (AKS 5 of 6, CKS 3 of 3), vBCL2 (AKS 6 of 6; CKS 3 of 3), and vIRF1 (AKS 5 of 6, CKS 3 of 3) transcripts were detected in both AKS and CKS, vGCR and HIV-1 Tat were expressed only in AKS samples (vGCR: AKS 3 of 6, CKS 0 of 3; Tat: AKS 4 of 6, CKS 0 of 3). vMIPII, vCBP, and vIL6 expression were not detected in any KS samples.
|
10662620 |
2000 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pattern of viral (HHV-8 v-cyclin) and cellular (p27Kip1) regulators of cell cycle expressed by CRO-AP/6, together with the results of growth fraction analysis, point to abrogation of the physiological inverse relationship between proliferation and p27Kip1 expression.
|
10914556 |
2000 |
|
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The remaining cases were negative or weakly staining; v-cyclin transcript load was higher in early Kaposi sarcoma.
|
10645225 |
1999 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that v-cyclin may exert both growth-promoting and apoptotic functions in KS, depending on factors regulating CDK6 and v-Bcl-2 levels.
|
10519412 |
1999 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) encodes a functional cyclin (vCYC) which is expressed during latency and can direct phosphorylation of pRB.
|
9882349 |
1999 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In situ hybridization indicated that mRNAs for v-cyclin D and kaposin, an HHV-8 latency-associated gene, were present in approximately 1% of the spindle cells in early patch lesions and approximately 60% of the spindle cells in late nodular lesions of Kaposi's sarcoma.
|
9414174 |
1997 |