|
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
Hypomorphic PCNA mutation underlies a human DNA repair disorder.
|
24911150 |
2014 |
|
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Hypomorphic PCNA mutation underlies a human DNA repair disorder.
|
24911150 |
2014 |
|
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Hepatoblastoma
|
0.510 |
Therapeutic
|
disease |
RGD |
Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma.
|
23219601 |
2013 |
|
Hepatoblastoma
|
0.510 |
AlteredExpression
|
disease |
BEFREE |
To evaluate Bcl-xL, Bax, PCNA, cytokeratin 19 (CK-19), glycogen content and DNA ploidy expression in hepatoblastoma (HB) and their prognostic value.
|
20803149 |
2010 |
|
Hepatoblastoma
|
0.510 |
Biomarker
|
disease |
CTD_human |
On the individual data for both TGF-alpha and PCNA, most of the HBs showed higher positive rates than HCCs.
|
11560253 |
2002 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our results unraveled a novel regulatory of GSK3β by PCNA and provided a promising direction for treatment of lung cancer.
|
31607135 |
2020 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In order to explore the application value of DCE-MRI in clinical diagnosis and treatment, guide early clinical diagnosis, evaluate prognosis, guide clinical selection of treatment options and improve medical level, the expression of adenocarcinoma, its relationship with clinicopathology, and the significance of co-expression of the proliferating cell nuclear antigen (PCNA), Ki67 protein and cyclooxygenase 2 (COX-2) in breast cancer are analyzed.
|
31289003 |
2019 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that targeting PCNA with PCNA-I1S may provide a novel approach for enhancing the efficacy of chemotherapy and radiation therapy in treatment of human prostate and lung cancer.
|
31600334 |
2019 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The reverse transcription quantitative polymerase chain reaction analysis revealed that PCNA‑1 was significantly upregulated (up to 5‑fold) in the lung cancer cells (P<0.05), and the overexpression of miR‑204 caused the downregulation of PCNA‑1 in A549 lung cancer cells.
|
30628638 |
2019 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
The tumor's cellularity, the Ki-67 positivity rate and PCNA, together with the clinical stage and the histological differentiation bring extra pieces of useful information in order to anticipate the evolution and the prognosis of lung cancer.
|
29940632 |
2018 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Meanwhile, the combination suppressed PCNA and NF-κB pathway in 4 kinds of lung cancer cells.
|
29608021 |
2018 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of TIM-4 promoted lung cancer cell growth and proliferation, and upregulated the expression of PCNA, cyclin A, cyclin B1 and cyclin D1, accompanied by accumulation of lung cancer cells in S phase.
|
26512878 |
2015 |
|
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men.
|
24012694 |
2013 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin E-driven transgenic lung cancers expressed a gene profile implicating HH pathway activation.
|
22923130 |
2012 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention.
|
21149327 |
2010 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show that mono-allelic loss of pten in the probasin-driven-ErbB-2 model resulted in increased nuclear cyclin D1 and proliferating cell nuclear antigen levels and decreased disease latency compared to either individual genetic model and, unlike the probasin-driven-ErbB-2 mice, progression to adenocarcinoma.
|
19443706 |
2009 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.
|
19028472 |
2009 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
Helicobacter pylori-induced changes in the gastric mucosa are associated with mitogen-activated protein kinase (MAPK) activation.
|
17525639 |
2007 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin E expression negatively affects lung cancer prognosis.
|
17360482 |
2007 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Biopsies of all 10 metastatic tumours (3 melanoma, 4 carcinoma and 3 adenocarcinoma) as well as 4 glioblastoma multiforme were positive for PCNA immunoexpression and supported the replication of HSV1716.
|
12898637 |
2003 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
CTD_human |
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
|
11884234 |
2002 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that YB-1 expression correlates with Topo IIalpha and PCNA expression in lung cancer.
|
11724293 |
2001 |
|
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prognostic role of cyclin D1 in lung cancer. Relationship to proliferating cell nuclear antigen.
|
10101007 |
1999 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These results demonstrated a progressive immunoreactivity for PCNA in the HP to AC sequence, while p53 positivity and aneuploidy seemed specific for colon carcinoma.
|
9673389 |
1998 |