Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Altogether, this suggests a potential role for ANGPTL4 in DN perhaps through its role in inhibiting LPL activity and promotes ANGPTL4 as a biochemical marker for the detection of a diabetic kidney disease in patients with T2D. 31772941 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Accumulating evidence associates ANGPTL4 directly with the risk of atherosclerosis and type 2 diabetes (T2D). 31235370 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE There is evidence that carrier status of ANGPTL4 loss-of-function variants may also influence risk of type 2 diabetes. 30893111 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression disease BEFREE Similarly, ANGPTL4 and ANGPTL8 levels were also elevated in subjects with T2D and hypertension than in those with T2D but not hypertension. 29490644 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE The 40Lys variant in ANGPTL4 was associated with protection from coronary disease and type 2 diabetes in groups with genetically higher or lower LDL-C. For a genetic difference of 0.23 SDs in LDL-C, ANGPTL3 loss-of-function variants, which also have beneficial associations with LPL lipolysis, were associated with greater protection against coronary disease than other LDL-C-lowering genetic mechanisms (ANGPTL3 loss-of-function variants: odds ratio, 0.66; 95% CI, 0.52-0.83; 58 LDL-C-lowering variants: odds ratio, 0.90; 95% CI, 0.89-0.91; P for heterogeneity = .009). 30326043 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE To investigate whether angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are differentially associated with the severity of retinopathy in patients with type 2 diabetes mellitus (T2DM). 29621508 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression disease BEFREE Angiopoietin-like protein 4 (ANGPTL-4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. 29536615 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Through a focus on mutations predicted to result in a loss of gene function and a phenome-wide association study, we propose novel indications for pharmaceutical inhibitors targeting PCSK9 (abdominal aortic aneurysm), ANGPTL4 (type 2 diabetes) and PDE3B (triglycerides and coronary disease). 30275531 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE In conclusion, genetic inactivation of ANGPTL4 is associated with improved glucose homeostasis and reduced risk of T2D. 29899519 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression disease BEFREE Serum ANGPTL4 levels were higher in obese subjects without/with T2DM (94.50 ± 9.51 and 134.19 ± 7.69 vs. 50.34 ± 4.22 ng/ml, p < 0.001) and lower in subjects with AN relative to healthy control subjects (38.22 ± 4.48 vs. 65.80 ± 7.98 ng/ml, p = 0.002), while serum ANGPTL3 levels demonstrated inverse tendency. 29695708 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD. 29083408 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression disease BEFREE ANGPTL4 levels in the plasma and HDLs were 1.7- and 2.0-fold higher in T2DM patients than nondiabetic controls, respectively (<i>P</i><0.0001). 28645936 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE ANGPTL8 associates with ANGPTL3 in the non-diabetic subjects while it associated more with ANGPTL4 in the obese and T2D subjects. 27733177 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE Therefore, we asked whether genetic variation within the ANGPTL4 gene contributes to prediabetic phenotypes, such as dyslipidemia, insulin resistance, or beta-cell dysfunction, in white subjects at an increased risk for type 2 diabetes mellitus. 18442626 2008