|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
CTD_human |
PLCE1 and C20orf54 have important biological implications for both ESCC and GCA.
|
20729853 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
PLCE1 and C20orf54 have important biological implications for both ESCC and GCA.
|
20729853 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
CTD_human |
A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34).
|
20729852 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34).
|
20729852 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus in genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) that share similar risk factors with SCCHN.
|
21689432 |
2011 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PLCE1 SNP rs2274223 A>G change may reduce gene expression, and the variant G genotypes might contribute to risk of ESCC.
|
22203178 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent large-scale genome-wide association studies (GWAS) reported that functional genetic variations in the phospholipase C epsilon gene (PLCE1) were strongly associated with risk of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) in Chinese population.
|
22744421 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results highlighted the role of a genetic factor in ESCC and suggested that the PLCε1 rs2274223 SNP might be an effective genetic marker to assess the risk of ESCC in individuals with a UGIC family history from a region of high incidence in northern China.
|
23079034 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We genotyped five PLCE1 variants in cases and controls, and found association of rs17417407" genes_norm="51196">Arg548Leu (rs17417407) with a reduced risk of OSCC (OR = 0.74, 95% CI = 0.60-0.93, P = 0.008) in the Black population.
|
22865593 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that genetic variants in PLCE1 might serve as candidate markers for Kazakh ESCC susceptibility, and these LD variants might influence ESCC risk individually and jointly by promoting the messenger RNA and protein expression of the gene.
|
23981775 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A statistically significant increase in the risk of ESCC was associated with the PLCE1 rs2274223 polymorphism.
|
23826241 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this study demonstrates for the first time that PLCE1 overexpression correlates with lymph node metastasis and advanced TNM stages of Kazakh ESCC, implicating a role of PLCE1 in cancer metastasis and aggressiveness in ethnic Kazakh patients with ESCC.
|
23659763 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results further confirmed that genetic variations in PLCE1 may contribute to ESCC risk associated with tobacco exposure in a central Chinese population.
|
23688607 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the modulation of the risk of ESCC in Asians, it is unlikely that the PLCE1 rs2274223 and RFT2 13042395 SNPs play a role in EAC or ESCC susceptibility in Dutch Caucasians.
|
23222411 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In stratified analysis by ethnicity, significant association of PLCE1 rs2274223 G allele and the risk of ESCC (OR=1.33, 95% CI 1.21-1.45) and GCA (OR =1.56, 95% CI: 1.47-1.64) was observed in Chinese population.
|
23874915 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
|
25129146 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PLCE1 polymorphisms were not associated with susceptibility to ESCC or its clinical phenotypes (tumor location/lymph node metastasis).
|
25139097 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Compared with normal tissues, PLCE1 mRNA expression was significantly reduced in ESCC tumors (P = 0.03, probe_205112_at), as well as in GCA and GNCA tumors (P < 0.0001, each probe).
|
24867265 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, PLCE1 rs2274223 polymorphism may be used as a potential biomarker for DTC susceptibility particularly for ESCC and GCA in the Chinese population.
|
24874112 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Using RevMan5.2 software, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of PLCE1 expression with clinicopathological features relative to ESCC or GCA.
|
25520085 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
We therefore designed PLCE1-special small interfering RNA and transfected to esophageal squamous cell (EC) 9706 cells to investigate the effects of PLCE1 gene silencing on the cell cycle and apoptosis of ESCC and indicate its important role in the development of ESCC.
|
25041015 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrated that PLCE1 rs2274223 A > G polymorphism may be associated with increased susceptibility to cancer, especially for ESCC.
|
25614244 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that genetic polymorphisms of phospholipase C epsilon 1 and C20orf54 are also associated with ESCC in a Korean population.
|
24152165 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Moreover, miR-145 was expressed at low levels in a large cohort of patients with ESCC and was inversely correlated with PLCE1 protein expression in cancer cells and tissues.
|
26657507 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Moreover, PLCE1 is overexpressed in ESCC tumors and promotes tumorigenicity <i>in vivo</i> and vitro.
|
29190930 |
2017 |