|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72-0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12-1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11-1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74-0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10-1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78-0.98) in overall population.
|
30784231 |
2019 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Presently, the single nucleotide polymorphisms (SNPs) of EGFR/PLCE1 genes and their associations with EC survival remain unclear.
|
31209807 |
2019 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In additional, five variants on five genes were rated as strong cumulative epidemiological evidence for a nominally significant association with EC and ESCC risk, including CYP1A1 rs1048943, EGF rs444903, HOTAIR rs920778, MMP2 rs243865, and PLCE1 rs2274223, 10 variants were rated as moderate, and 18 variants were rated as weak.
|
30793520 |
2019 |
|
Malignant neoplasm of esophagus
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Finally, high expression of both PLCE1 and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers.
|
28402280 |
2017 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two genome-wide association studies have identified variants in PLCE1 at 10q23 that are significantly associated with esophageal cancer risk.
|
28007352 |
2017 |
|
Malignant neoplasm of esophagus
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, the causative role of PLCE1 in esophageal cancer is not clear.
|
28147304 |
2017 |
|
Malignant neoplasm of esophagus
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hence, delivery of PLCE1-targeting miR-145 is a potential therapeutic approach for esophageal cancer.
|
26657507 |
2016 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The PLCE1 rs2274223 polymorphism has a relationship with family history of esophageal cancer, but does not have any significant association with age, gender, smoking, alcohol drinking, food hygiene, eating habits, living around the environment and occupation in cases.
|
25854357 |
2015 |
|
Malignant neoplasm of esophagus
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The level of PLCE1 protein in esophageal cancer tissue was significantly higher than that in normal tissue.
|
25041015 |
2014 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis provides strong statistical evidence for an elevated risk of EC associated with PLCE1 rs2274223.
|
24737582 |
2014 |
|
Malignant neoplasm of esophagus
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The results showed that Eca cell lines, OE33 and CP-C cells expressed high levels of PLCE1.
|
24766303 |
2014 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in PLCE1 modulate risk of EC in the high risk Kashmiri population.
|
24935391 |
2014 |
|
Malignant neoplasm of esophagus
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Overall, we determined that PLCE1 expression was associated with tumor progression in both esophageal cancers (pooled OR=5.93; 95%CI=3.86 to 9.11) and gastric cancers (pooled OR=9.73; 95%CI=6.46 to 14.7).
|
25520085 |
2014 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The PLCE1 rs2274223 polymorphism was thus associated with risk of esophageal cancer in all genetic models.
|
25422186 |
2014 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population.
|
25139097 |
2014 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, three genome-wide association studies of esophageal cancer have identified a shared susceptibility locus at 10q23 (rs2274223: A5780G) in phospholipase C epsilon 1 (PLCE1).
|
24127316 |
2014 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population.
|
23981775 |
2013 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Stratified analyses indicated a significantly increased risk of esophageal cancer associated with the PLCE1 rs2274223 AG genotype was more evident among females, younger patients and never drinkers, compared with the PLCE1 rs2274223 AA genotypes.
|
22744421 |
2012 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
|
21689432 |
2011 |
|
Malignant neoplasm of esophagus
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
|
21642993 |
2011 |