CDKL3, cyclin dependent kinase like 3, 51265

N. diseases: 5; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma
0.010 Biomarker disease BEFREE Given the high level of CDKL3 expression in human cholangiocarcinoma tissues and cell lines, we speculated that CDKL3 may constitute a potential biological target for curcumol in cholangiocarcinoma. 29615928 2018
Squamous cell carcinoma of esophagus
0.010 AlteredExpression disease BEFREE Additionally, the association between the survival and CDKL3 expression in ESCC were evaluated based on the TCGA data. 30387188 2018
CUI: C0026106
Disease: Mild Mental Retardation
Mild Mental Retardation
0.010 GeneticVariation disease BEFREE Together the data suggest that haploinsufficiency of CDKL3 in the t(X;5) patient contributes to her phenotype, and that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant MR. 18412109 2008
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.010 GeneticVariation group LHGDN Inactivation of the CDKL3 gene at 5q31.1 by a balanced t(X;5) translocation associated with nonspecific mild mental retardation. 18412109 2008
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME
0.010 Biomarker group BEFREE NKIAMRE loss may be an important determinant of dysmyelopoiesis. 10463609 1999