|
Acute hepatitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Several reports also noted the increased levels of GP73 expression in chronic liver disease in patients with acute hepatitis of various etiologies, chronic Hepatitis C virus (HCV) infection and alcoholic liver disease.
|
24351813 |
2013 |
|
Acute hepatitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GP73 expression was detected immunohistochemically and by immunofluorescence microscopy in patients with acute hepatitis of various etiologies, autoimmune hepatitis, chronic HCV infection, and alcoholic liver disease.
|
15180730 |
2004 |
|
Acute-On-Chronic Liver Failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further ELISA analysis confirmed the significant up-regulation of GP73, MMR, OPN and down-regulation of ATIII, HPX, APO-CII in HBV-ACLF plasma samples (<i>p</i> < 0.01).
|
29270132 |
2017 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrate that the structure of the Golgi is fragmented and the intracellular localisation of GOLPH2 is altered in BO and oesophageal adenocarcinoma tissue.
|
26461057 |
2015 |
|
Adenocarcinoma of lung (disorder)
|
0.310 |
Biomarker
|
disease |
BEFREE |
Based on these findings, we infer that GOLM1 might serve as a valuable prognostic biomarker in LUAD, but not in LUSC.
|
29843532 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.310 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
GOLM1 silencing inhibits the proliferation and motility of human glioblastoma cells via the Wnt/β-catenin signaling pathway.
|
30935831 |
2019 |
|
Adult Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effect of GP73 silencing on proliferation and apoptosis in hepatocellular cancer.
|
25170213 |
2014 |
|
Adult Liver Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Golgi Protein 73 (GP73) is a newly identified diagnostic and prognostic marker for liver cancer.
|
29552166 |
2018 |
|
Adult Liver Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The results proved that the novel GOLPH2-regulated GD55 conferred higher adenovirus replication and infectivity for liver cancer cells than oncolytic adenovirus ZD55.
|
25980438 |
2015 |
|
Adult Liver Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
GP73 has drawn increasing attention for its potential application in the diagnosis of liver diseases such as hepatitis, liver cirrhosis and liver cancer.
|
30341783 |
2019 |
|
Alcoholic Liver Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Several reports also noted the increased levels of GP73 expression in chronic liver disease in patients with acute hepatitis of various etiologies, chronic Hepatitis C virus (HCV) infection and alcoholic liver disease.
|
24351813 |
2013 |
|
Alcoholic Liver Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Increased levels of GP73 expression were also noted in chronic HCV infection and alcoholic liver disease.
|
15180730 |
2004 |
|
ALZHEIMER DISEASE 5
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transfection of GP73-SphK1sR-Ad5 significantly upregulated E1A and downregulated SphK1 in Huh7 cells, but not in HL7702 cells.
|
31749347 |
2020 |
|
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism, rs10868366, in the Golgi phosphoprotein 2 gene, GOLM1, was recently identified as an AD risk factor in a genome-wide association study.
|
20570408 |
2012 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
We found no evidence of association between GOLPH2 markers and susceptibility to Alzheimer's disease in our series.
|
19749441 |
2009 |
|
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Genomewide association (GWA) studies have recently implicated 4 novel Alzheimer disease (AD) susceptibility loci (GAB2, GOLM1, and 2 uncharacterized loci to date on chromosomes 9p and 15q).
|
19204163 |
2009 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The growth and motility of the PDAC cells was enhanced following overexpression of GOLPH2, whereas downregulating the expression of GOLPH2 impaired the growth, motility and tumorigenesis.
|
29344673 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Treatment of autoimmune hepatitis was associated with a normalization of GP73 expression, indicating that the initial upregulation was reversible.
|
15180730 |
2004 |
|
Autoimmune hepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Treatment of autoimmune hepatitis was associated with a normalization of GP73 expression, indicating that the initial upregulation was reversible.
|
15180730 |
2004 |
|
Barrett Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrate that the structure of the Golgi is fragmented and the intracellular localisation of GOLPH2 is altered in BO and oesophageal adenocarcinoma tissue.
|
26461057 |
2015 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that GP73 promotes bladder cancer invasion and metastasis by inducing the EMT through down-regulating WT1 levels and activating the TGF-β1/Smad2 signalling pathway.
|
29349903 |
2018 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using five bioinformatics analysis software, we identified Golgi protein 73 (GP73) as a putative target of microRNA-27b (miR-27b), which is closely related to various biological processes or diseases such as bone metabolism disease, adipose cell and muscle cell development, pulmonary hypertension, cervical cancer, and breast cancer.
|
30418194 |
2019 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MATERIAL AND METHODS The expression of GOLM1 in BC tissues and cell lines was detected by using qRT-PCR assay.
|
30695018 |
2019 |
|
Candidemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among them, a cytokine QTL at the NAA35-GOLM1 locus markedly modulated interleukin (IL)-6 production in response to multiple pathogens and was associated with susceptibility to candidemia.
|
27376574 |
2016 |