|
Influenza
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Application of Gui Zhi Ma Huang Ge Ban Tang in influenza-infected mice in a cold environment showed (i) downregulation of TLR7, MyD88, and NF-<i>κ</i>Bp65; (ii) inhibition of transcriptional activities of promoters coding for TLR7, MyD88, and NF-<i>κ</i>Bp65; (iii) reduction in the proportion of Th1/Th2 and Th17/Treg cells.
|
29849712 |
2018 |
|
Influenza
|
0.090 |
Biomarker
|
disease |
BEFREE |
Taken together, these data illustrate that greater TLR7 activation and antibody production in females improves the efficacy of vaccination against influenza.
|
30455317 |
2018 |
|
Influenza
|
0.090 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that the combination of synthetic small-molecule Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent adjuvant for recombinant influenza virus hemagglutinin, inducing rapid and sustained immunity that is protective against influenza viruses in homologous, heterologous, and heterosubtypic murine challenge models.
|
28724768 |
2017 |
|
Influenza
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Here, we characterized, using RNA sequencing, the transcriptional response of primary monocytes from Africans and Europeans to bacterial and viral stimuli-ligands activating Toll-like receptor pathways (TLR1/2, TLR4, and TLR7/8) and influenza virus-and mapped expression quantitative trait loci (eQTLs).
|
27768888 |
2016 |
|
Influenza
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
2R9 diminished systemic cytokine responses elicited in vivo by synthetic TLR2 and TLR7 agonists; it inhibited the activation of macrophages infected with influenza strain A/PR/8/34 (PR8) and significantly improved the survival of PR8-infected mice.
|
26095366 |
2015 |
|
Influenza
|
0.090 |
Biomarker
|
disease |
BEFREE |
There were increased cellular expressions of TLR9, TLR8, TLR3, and TLR7 during influenza; TLR2 and TLR4 were suppressed.
|
23552014 |
2013 |
|
Influenza
|
0.090 |
Biomarker
|
disease |
BEFREE |
Therefore, the MyD88-dependent pathway of TLR7 was involved in the early stage of antiviral innate immune response in geese during H5N1 HPAIV infection.
|
23481654 |
2013 |
|
Influenza
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To analyze the immunogenicity of these domains, we used plasmacytoid dendritic cells (pDCs). pDCs express pattern recognition receptors, including Toll-like receptor 7 (TLR7), which recognizes guanosine- and uridine-rich viral single-stranded RNA (ssRNA), including influenza virus ssRNA.
|
21307198 |
2011 |
|
Influenza
|
0.090 |
Biomarker
|
disease |
BEFREE |
The result showed that SAT05f could down-regulate TLR7/9-dependent IFN-alpha production in cultured human PBMC stimulated by inactivated Flu virus PR8 or HSV-1 or CpG ODN or imiquimod, protect d-GalN-treated mice from lethal shock induced by TLR9 agonist, not by TLR3/4 agonist.
|
20034855 |
2010 |