Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
In <i>in vivo</i> analyses, the simultaneous presence of TGF-β and IL-10 effectively suppressed TLR-mediated antigen-specific immune responses and ameliorated pathologies in imiquimod (TLR7 agonist)-induced lupus model and lupus-prone MRL/<i>lpr</i> mice.
|
29963056 |
2018 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, using spontaneous murine models of lupus (i.e., BXSB/MpJ and NZB/W F1 mice), we demonstrate that administration of Gal-9 results in reduced TLR7-mediated autoimmune manifestations.
|
29611821 |
2018 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
The differential roles of PAD2 and PAD4 in TLR-7-dependent lupus autoimmunity were examined.
|
30518690 |
2018 |
Lupus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, our data suggest that excessive expression of IFN-I through the activation of TLR7/9 signaling may induce accelerated atherosclerosis in lupus through the depletion or dysfunction of EPCs, suggesting that targeting IFN-I might have potential therapeutic effects on both lupus disease and premature atherosclerosis in SLE patients.
|
30108025 |
2018 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that enhanced TLR7 responses of lupus pDCs, owing to TLR7 retention in late endosome/lysosome and exposure to IFN-α, are associated with the pathogenesis of SLE.
|
29052537 |
2017 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the contrary, Genista mice deprived of TLR7 did not show any of these phenotypes, suggesting that the observed lupus autoimmunity in Genista mice is TLR7-dependent.
|
27600904 |
2016 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further confirm our results, we established another lupus model by topically treating C57BL/6 (B6) mice with the TLR-7 agonist imiquimod (IMQ) for 8 weeks according to the previously described protocol.
|
26144250 |
2016 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although autoantibodies and glomerulonephritis are type I IFN dependent, lupus-associated BM abnormalities were TLR-7 and TNFα driven but type I IFN independent, suggesting that lupus is a disorder of innate immunity in which TLR-7 activation by phagocytosed nuclei causes relentless type I IFN and TNFα production mediating glomerulonephritis and hematologic involvement, respectively.
|
24449581 |
2014 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice that overexpress TLR7 develop a lupus-like disease with autoantibodies and glomerulonephritis and early death.
|
23382559 |
2013 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, we discuss the rationale for self-recognition by TLR7 and TLR9 as an important part of the development of lupus and other autoimmune diseases.
|
18613842 |
2008 |
Lupus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that up-regulated expression of TLR7 and TLR9 mRNAs together with increased expression of IFN-alpha mRNA in PBMCs may also contribute to the pathogenesis of human lupus.
|
18373699 |
2008 |
Lupus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine whether there is an increase in the number of TLR7 gene copies in patients diagnosed as having systemic lupus erythematosus (SLE) and whether gene amplification influences the autoantibody profiles in SLE patients, as has recently been reported in the BXSB/Yaa mouse model of lupus.
|
17907191 |
2007 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms.
|
18034431 |
2007 |