TLR7, toll like receptor 7, 51284

N. diseases: 276; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE In <i>in vivo</i> analyses, the simultaneous presence of TGF-β and IL-10 effectively suppressed TLR-mediated antigen-specific immune responses and ameliorated pathologies in imiquimod (TLR7 agonist)-induced lupus model and lupus-prone MRL/<i>lpr</i> mice. 29963056 2018
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE Here, using spontaneous murine models of lupus (i.e., BXSB/MpJ and NZB/W F1 mice), we demonstrate that administration of Gal-9 results in reduced TLR7-mediated autoimmune manifestations. 29611821 2018
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE The differential roles of PAD2 and PAD4 in TLR-7-dependent lupus autoimmunity were examined. 30518690 2018
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 AlteredExpression disease BEFREE Thus, our data suggest that excessive expression of IFN-I through the activation of TLR7/9 signaling may induce accelerated atherosclerosis in lupus through the depletion or dysfunction of EPCs, suggesting that targeting IFN-I might have potential therapeutic effects on both lupus disease and premature atherosclerosis in SLE patients. 30108025 2018
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE These findings indicate that enhanced TLR7 responses of lupus pDCs, owing to TLR7 retention in late endosome/lysosome and exposure to IFN-α, are associated with the pathogenesis of SLE. 29052537 2017
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE On the contrary, Genista mice deprived of TLR7 did not show any of these phenotypes, suggesting that the observed lupus autoimmunity in Genista mice is TLR7-dependent. 27600904 2016
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE To further confirm our results, we established another lupus model by topically treating C57BL/6 (B6) mice with the TLR-7 agonist imiquimod (IMQ) for 8 weeks according to the previously described protocol. 26144250 2016
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE Although autoantibodies and glomerulonephritis are type I IFN dependent, lupus-associated BM abnormalities were TLR-7 and TNFα driven but type I IFN independent, suggesting that lupus is a disorder of innate immunity in which TLR-7 activation by phagocytosed nuclei causes relentless type I IFN and TNFα production mediating glomerulonephritis and hematologic involvement, respectively. 24449581 2014
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE Mice that overexpress TLR7 develop a lupus-like disease with autoantibodies and glomerulonephritis and early death. 23382559 2013
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE In this review, we discuss the rationale for self-recognition by TLR7 and TLR9 as an important part of the development of lupus and other autoimmune diseases. 18613842 2008
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 AlteredExpression disease BEFREE These results suggest that up-regulated expression of TLR7 and TLR9 mRNAs together with increased expression of IFN-alpha mRNA in PBMCs may also contribute to the pathogenesis of human lupus. 18373699 2008
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 GeneticVariation disease BEFREE To determine whether there is an increase in the number of TLR7 gene copies in patients diagnosed as having systemic lupus erythematosus (SLE) and whether gene amplification influences the autoantibody profiles in SLE patients, as has recently been reported in the BXSB/Yaa mouse model of lupus. 17907191 2007
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris
0.100 Biomarker disease BEFREE Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. 18034431 2007