TLR7, toll like receptor 7, 51284

N. diseases: 276; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 Biomarker disease BEFREE Here, we examined the preventative effects of MHP1-AcN in a mouse model of imiquimod (a TLR 7/8 agonist)-induced psoriasis. 31659208 2019
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 PosttranslationalModification disease BEFREE In the present study, an imiquimod-induced psoriasis-like dermatitis mouse model was constructed under natural immune conditions and verified by evaluations of the Psoriasis Area and Severity Index (PASI) score and Baker score, H&E staining, immunohistochemical examination of the CD3 and Gr1 levels, measurement of plasmacytoid dendritic cell- (pDC) and Th17-associated cytokine levels, and evaluation of p65 phosphorylation and TLR7 expression. 30551443 2019
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 Biomarker disease BEFREE Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro. 29859222 2018
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 AlteredExpression disease BEFREE Activation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly used mouse model of psoriasis. 28935206 2018
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 Biomarker disease BEFREE Using a murine model of psoriasis induced by TLR7 agonist imiquimod (IMQ), we show that VISTA deficiency exacerbated psoriasiform inflammation. 28469254 2017
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 Biomarker disease BEFREE Imiquimod (IMQ), a TLR7/8 agonist, has been used to induce psoriasis in a mouse model. 28761880 2017
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 Biomarker disease BEFREE These results indicate that paeonol suppresses the maturation and activation of DCs by decreasing MyD88 and TLR8 proteins in the TLR7/8 signaling pathway which finally alleviates psoriasis‑like skin lesions. 28339016 2017
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 AlteredExpression disease BEFREE Mean TLR7 level in patients with MF (0.4 ± 0.23) was significantly lower than in patients with psoriasis (1.49 ± 0.46) and in HCs (1.22 ± 0.44) (P < 0.001), and mean TLR7 level in patients with psoriasis was significantly higher than in HCs (P < 0.03). 28054376 2017
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 Biomarker disease BEFREE TLR7 may play an important role in the pathogenesis of psoriasis through regulating the differentiation of the keratinocytes, and will give a new insight into the psoriasis. 24057248 2013
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 Biomarker disease BEFREE Our results demonstrate that the cationic antimicrobial peptide LL37 converts self-RNA into a trigger of TLR7 and TLR8 in human DCs, and provide new insights into the mechanism that drives the auto-inflammatory responses in psoriasis. 19703986 2009
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.100 AlteredExpression disease BEFREE For example, TLR7 and TLR9 activation by endogenous RNA and DNA, transported to the endosomes in the form of immune complexes or non-covalently associated with cationic peptides, could be an important mechanism involved in promoting diseases such as systemic lupus erythematosus and psoriasis. 18613842 2008