Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we examined the preventative effects of MHP1-AcN in a mouse model of imiquimod (a TLR 7/8 agonist)-induced psoriasis.
|
31659208 |
2019 |
Psoriasis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In the present study, an imiquimod-induced psoriasis-like dermatitis mouse model was constructed under natural immune conditions and verified by evaluations of the Psoriasis Area and Severity Index (PASI) score and Baker score, H&E staining, immunohistochemical examination of the CD3 and Gr1 levels, measurement of plasmacytoid dendritic cell- (pDC) and Th17-associated cytokine levels, and evaluation of p65 phosphorylation and TLR7 expression.
|
30551443 |
2019 |
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro.
|
29859222 |
2018 |
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly used mouse model of psoriasis.
|
28935206 |
2018 |
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using a murine model of psoriasis induced by TLR7 agonist imiquimod (IMQ), we show that VISTA deficiency exacerbated psoriasiform inflammation.
|
28469254 |
2017 |
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Imiquimod (IMQ), a TLR7/8 agonist, has been used to induce psoriasis in a mouse model.
|
28761880 |
2017 |
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that paeonol suppresses the maturation and activation of DCs by decreasing MyD88 and TLR8 proteins in the TLR7/8 signaling pathway which finally alleviates psoriasis‑like skin lesions.
|
28339016 |
2017 |
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mean TLR7 level in patients with MF (0.4 ± 0.23) was significantly lower than in patients with psoriasis (1.49 ± 0.46) and in HCs (1.22 ± 0.44) (P < 0.001), and mean TLR7 level in patients with psoriasis was significantly higher than in HCs (P < 0.03).
|
28054376 |
2017 |
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TLR7 may play an important role in the pathogenesis of psoriasis through regulating the differentiation of the keratinocytes, and will give a new insight into the psoriasis.
|
24057248 |
2013 |
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that the cationic antimicrobial peptide LL37 converts self-RNA into a trigger of TLR7 and TLR8 in human DCs, and provide new insights into the mechanism that drives the auto-inflammatory responses in psoriasis.
|
19703986 |
2009 |
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For example, TLR7 and TLR9 activation by endogenous RNA and DNA, transported to the endosomes in the form of immune complexes or non-covalently associated with cationic peptides, could be an important mechanism involved in promoting diseases such as systemic lupus erythematosus and psoriasis.
|
18613842 |
2008 |