|
Measles
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic variation in key innate pathogen recognition receptors, such as the measles cell entry receptors CD46 and SLAM, measles attachment receptor DC-SIGN, the antiviral toll-like receptors (TLR)3, TLR7 and TLR8, and the cytosolic antiviral receptor RIG-I, may significantly affect measles IgG antibody responses.
|
22871352 |
2012 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Given the role of TLR8 in autoimmunity, we also optimized the potency of <b>2</b> and developed a new TLR8 inhibitor bearing a 1,3,4-oxadiazole motif.
|
31687820 |
2019 |
|
Polyendocrinopathies, Autoimmune
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we show that 3 human monoclonal aPLs as well as IgG fractions from patients with the APS increase mRNA expression of the intracellular toll-like receptor (TLR) 7 in plasmacytoid dendritic cells and TLR8 in monocytes.
|
21734241 |
2011 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here we show that tumor-secreted miR-21 and miR-29a also can function by another mechanism, by binding as ligands to receptors of the Toll-like receptor (TLR) family, murine TLR7 and human TLR8, in immune cells, triggering a TLR-mediated prometastatic inflammatory response that ultimately may lead to tumor growth and metastasis.
|
22753494 |
2012 |
|
Rheumatoid Arthritis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here we showed that a quarter to a third of men with rheumatoid arthritis (RA) had significantly increased copy numbers (CN) of TLR7 gene and its paralog TLR8.
|
31501466 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we conducted trans-ancestral fine-mapping in 13,339 subjects including European Americans, African Americans, and Amerindian/Hispanics and confirmed rs3853839 as the only variant within the TLR7-TLR8 region exhibiting consistent and independent association with SLE (Pmeta = 7.5×10(-11), OR = 1.24 [1.18-1.34]).
|
23468661 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we report the implication of TLR7 signaling in high fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in TLR8-deficient (TLR8ko) mice, which develop spontaneous lupus-like disease due to increased TLR7 signaling by dendritic cells (DCs).
|
31552019 |
2019 |
|
Lupus Erythematosus
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we report the implication of TLR7 signaling in high fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in TLR8-deficient (TLR8ko) mice, which develop spontaneous lupus-like disease due to increased TLR7 signaling by dendritic cells (DCs).
|
31552019 |
2019 |
|
Lupus Vulgaris
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we report the implication of TLR7 signaling in high fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in TLR8-deficient (TLR8ko) mice, which develop spontaneous lupus-like disease due to increased TLR7 signaling by dendritic cells (DCs).
|
31552019 |
2019 |
|
Lupus Erythematosus, Discoid
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we report the implication of TLR7 signaling in high fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in TLR8-deficient (TLR8ko) mice, which develop spontaneous lupus-like disease due to increased TLR7 signaling by dendritic cells (DCs).
|
31552019 |
2019 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Here, we report the implication of TLR7 signaling in high fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in TLR8-deficient (TLR8ko) mice, which develop spontaneous lupus-like disease due to increased TLR7 signaling by dendritic cells (DCs).
|
31552019 |
2019 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High gene expression of TLR7 and TLR8 in melanoma tumors is associated with high expression levels of functional markers of immune cells, which predicts longer overall survival of patients with melanoma.
|
28919783 |
2017 |
|
Dengue Fever
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Higher frequency of TLR8 rs3764879–rs3764880 haplotype C-A was observed in male DF cases compared to male HC [P = 0.025 OR with 95% CI 2.185 (1.101–4.336)].
|
25446400 |
2015 |
|
Inflammatory Bowel Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
However, the role of TLR-8 in IBD is currently unknown, and therefore we investigated the expression of TLR-8 and its natural antagonist, Tollip, in normal and inflamed human gut, and examined whether the receptor is functionally active.
|
18985539 |
2009 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of TLR8 in chronic hepatitis B virus (HBV) infection is poorly understood.
|
28236535 |
2017 |
|
Autoimmune Diseases
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Illness may be caused by constitutive activation of human TLR7 or TLR8 in the bacterial artificial chromosome positive mice as increased TLR7 and TLR8 expression or activation has previously been implicated in autoimmune disease.
|
25229618 |
2014 |
|
X-linked agammaglobulinemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia.
|
17090647 |
2007 |
|
Agammaglobulinemia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia.
|
17090647 |
2007 |
|
Fibrosis, Liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TLR8 polymorphisms seem to be related to non-progression of liver fibrosis in HIV/HCV coinfected patients, particularly in males and those patients infected with GT1.
|
26455634 |
2015 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these findings provide evidence that TLR7 and TLR8 genetic polymorphisms are associated with susceptibility to MTB infection, and the link is shaped by less effective MTB phagocytosis and impaired TLR signaling.
|
27156628 |
2016 |
|
Respiratory Distress Syndrome, Adult
|
0.010 |
Biomarker
|
disease |
BEFREE |
In humans with Acute Respiratory Distress Syndrome (ARDS), we describe a potential role for TLR8 activation by circulating RNA ligands, as plasma and extracted RNA fractions from ARDS subjects activated TLR8 in vitro.
|
31385713 |
2020 |
|
Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In male participants, reduced susceptibility to periodontitis was observed in carriers of TLR7-rs3853839 (CC versus GG and CG, P = 0.02, OR 0.30, 95% CI 0.11-0.85) and TLR8-rs3764879 (CC versus GG and CG, P = 0.02, OR 0.31, 95% CI 0.12-0.82).
|
30517775 |
2019 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In men, TLR1, TLR2, and TLR3 were associated with lipid and TLR8 with hypertension treatment.
|
25657311 |
2015 |
|
Tuberculosis, Pulmonary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In summary, we show an association of SNP TLR8 rs3764880 with PTB in the Moldavian male population, providing support to previous studies conducted on other populations.
|
30529560 |
2019 |
|
Psoriasiform eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we found that <i>Il1f6</i><sup>-/-</sup> mice developed milder psoriasiform dermatitis upon treatment with imiquimod, a ligand for TLR ligand 7 (TLR7) and TLR8, whereas <i>Il1f6</i><sup>-/-</sup> mice showed similar susceptibility to dextran sodium sulfate-induced colitis to wild-type mice.
|
29794016 |
2018 |