Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1834129
Disease: Abnormal vertebral morphology
Abnormal vertebral morphology
0.100 Biomarker phenotype HPO
CUI: C3164374
Disease: Abnormality of pulmonary valve
Abnormality of pulmonary valve
0.100 Biomarker disease HPO
CUI: C1846460
Disease: Abnormality of the outer ear
Abnormality of the outer ear
0.100 Biomarker disease HPO
CUI: C1842083
Disease: Abnormality of the ribs
Abnormality of the ribs
0.100 Biomarker disease HPO
CUI: C4024162
Disease: Abnormality of the tragus
Abnormality of the tragus
0.100 Biomarker phenotype HPO
CUI: C4025846
Disease: Abnormality of vision
Abnormality of vision
0.100 Biomarker disease HPO
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.010 AlteredExpression disease BEFREE We found that expression of the Wnt inhibitors sFRP1, sFRP2, sFRP4, sFRP5, WIF1, Dkk3, and Hdpr1 was down-regulated due to abnormal promoter methylation in ALL cell lines and samples from patients with ALL. 17148581 2007
CUI: C0751606
Disease: Adult Acute Lymphocytic Leukemia
Adult Acute Lymphocytic Leukemia
0.010 AlteredExpression disease BEFREE We found that expression of the Wnt inhibitors sFRP1, sFRP2, sFRP4, sFRP5, WIF1, Dkk3, and Hdpr1 was down-regulated due to abnormal promoter methylation in ALL cell lines and samples from patients with ALL. 17148581 2007
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum
0.100 Biomarker disease HPO
CUI: C0002902
Disease: Anencephaly
Anencephaly
0.100 Biomarker disease HPO
CUI: C1838705
Disease: Anteriorly placed anus
Anteriorly placed anus
0.100 Biomarker phenotype HPO
CUI: C0003466
Disease: Anus, Imperforate
Anus, Imperforate
0.110 Biomarker disease HPO
CUI: C0003466
Disease: Anus, Imperforate
Anus, Imperforate
0.110 Biomarker disease BEFREE A heterozygous nonsense variant was identified in dapper, antagonist of beta-catenin, 1 (DACT1) via whole-exome sequencing in family members with imperforate anus, structural renal abnormalities, genitourinary anomalies, and/or ear anomalies. 28054444 2017
CUI: C1862698
Disease: Aplasia/Hypoplasia of the 3rd toe
Aplasia/Hypoplasia of the 3rd toe
0.100 Biomarker phenotype HPO
CUI: C0003803
Disease: Arnold Chiari Malformation
Arnold Chiari Malformation
0.100 Biomarker disease HPO
CUI: C0004096
Disease: Asthma
Asthma
0.010 AlteredExpression disease BEFREE DACT1, DACT2 and DACT3 were significantly upregulated in specimens from children with asthma compared with controls (P<0.05) and the expression of DACT1 was significantly more increased compared with DACT2 and DACT3 (P<0.05). 29456669 2018
CUI: C0018817
Disease: Atrial Septal Defects
Atrial Septal Defects
0.100 Biomarker group HPO
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
0.010 Biomarker disease BEFREE The clinical significance of aberrant promoter methylation of the canonical Wnt pathway antagonist genes (sFRP1, sFRP2, sFRP4, sFRP5, Wif1, Dkk3, and Hdpr1) and also putative tumor-suppressor gene Wnt5a, belonging to the non-canonical Wnt signaling pathway, was investigated in a large series of 75 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia by methylation-specific polymerase chain reaction. 18549404 2008
CUI: C0341787
Disease: Bifid scrotum
Bifid scrotum
0.100 Biomarker disease HPO
CUI: C1850327
Disease: Bifid uterus
Bifid uterus
0.100 Biomarker phenotype HPO
CUI: C0005744
Disease: Blepharophimosis
Blepharophimosis
0.100 Biomarker disease HPO
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 AlteredExpression disease BEFREE Demethylation treatment of breast cancer cell lines restored DACT1 expression along with promoter demethylation, suggesting that an epigenetic mechanism mediates DACT1 silencing in breast cancer. 23497530 2013
CUI: C4021343
Disease: Broad hallux phalanx
Broad hallux phalanx
0.100 Biomarker disease HPO
CUI: C0426891
Disease: Broad thumbs
Broad thumbs
0.100 Biomarker phenotype HPO
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.030 AlteredExpression phenotype BEFREE Ectopic expression of DACT1 in silenced gastric cancer cell lines (AGS, BGC823 and MGC803) by stable transfection suppressed colony formation (P < 0.001), induced cell apoptosis (P < 0.01) and retarded tumorigenesis in nude mice (P < 0.001). 23073659 2012