|
Acrodysostosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance.
|
23043190 |
2012 |
|
Acrodysostosis
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Acrodysostosis
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Identification of novel mutations confirms PDE4D as a major gene causing acrodysostosis.
|
23033274 |
2013 |
|
Mental Depression
|
0.500 |
Biomarker
|
disease |
RGD |
The rat model confirms Pde4d's role in depression but not in spatial learning or memory enhancement and shows for the first time higher fear conditioning and altered extinction compared with controls.
|
22487514 |
2012 |
|
Mental Depression
|
0.500 |
Biomarker
|
disease |
PSYGENET |
The rat model confirms Pde4d's role in depression but not in spatial learning or memory enhancement and shows for the first time higher fear conditioning and altered extinction compared with controls.
|
22487514 |
2012 |
|
Mental Depression
|
0.500 |
Biomarker
|
disease |
PSYGENET |
These results suggest that PDE4D is an essential mediator of the antidepressant-like effects of rolipram, and that PDE4D-regulated cyclic adenosine monophosphate signaling may play a role in the pathophysiology and pharmacotherapy of depression.
|
12377395 |
2002 |
|
ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Asthma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs, rs1544791 (PDE4D) and rs3806932 (TSLP), were more strongly associated with the high smoking history subgroup than with asthma or any other subgroups.
|
27058054 |
2016 |
|
Asthma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Our rank-based genome-wide analysis revealed for the first time an association of RYR2 variants with asthma and replicated previously discovered PDE4D asthma gene across human populations.
|
23829686 |
2013 |
|
Asthma
|
0.470 |
Biomarker
|
disease |
BEFREE |
An important genetic component to asthma susceptibility has long been recognized, most recently through the identification of several genes (e.g., ORMDL3, PDE4D, HLA-DQ, and TLE4) via genome-wide association studies.
|
23181788 |
2012 |
|
Asthma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Long-acting β(2)-agonists are now contraindicated as monotherapy for asthma, and increased PDE4D has been speculated to contribute to this phenomenon.
|
22101762 |
2012 |
|
Asthma
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
Asthma
|
0.470 |
Biomarker
|
disease |
CTD_human |
β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.
|
21611147 |
2011 |
|
Asthma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
We sought to search for new variants associated with asthma and attempt to replicate the association with four loci reported previously (ORMDL3, PDE4D, DENND1B and IL1RL1).
|
21150878 |
2011 |
|
Asthma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Gene-based analyses that included all available SNPs in each gene found associations (P < .05) with both phenotypes for several genes: neuronal growth regulator 1 (NEGR1); roundabout, axon guidance receptor, homolog 1 (ROBO1); diacylglycerol kinase, gamma (DGKG); Fas apoptotic inhibitory molecule 2 (FAIM2); fat mass and obesity associated (FTO); and carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 (CHST8) among the BMI GWAS genes; interleukin 1 receptor-like 1 / interleukin 18 receptor 1 (IL1RL1/IL18R1), dipeptidyl-peptidase 10 (DPP10), phosphodiesterase 4D (PDE4D), V-myb myeloblastosis viral oncogene homolog (MYB), PDE10A, IL33, and especially protein tyrosine phosphatase, receptor type D (PTPRD) among the asthma GWAS genes; and protein kinase C, alpha (PRKCA) among the BMI and asthma candidate genes.
|
20816195 |
2010 |
|
Asthma
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
Asthma-susceptibility variants identified using probands in case-control and family-based analyses.
|
20698975 |
2010 |
|
Asthma
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
The phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) gene (PDE4D) is a regulator of airway smooth-muscle contractility, and PDE4 inhibitors have been developed as medications for asthma.
|
19426955 |
2009 |
|
Asthma
|
0.470 |
Biomarker
|
disease |
CTD_human |
The phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) gene (PDE4D) is a regulator of airway smooth-muscle contractility, and PDE4 inhibitors have been developed as medications for asthma.
|
19426955 |
2009 |
|
Asthma
|
0.470 |
Biomarker
|
disease |
BEFREE |
The phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) gene (PDE4D) is a regulator of airway smooth-muscle contractility, and PDE4 inhibitors have been developed as medications for asthma.
|
19426955 |
2009 |
|
Asthma
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
The phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) gene (PDE4D) is a regulator of airway smooth-muscle contractility, and PDE4 inhibitors have been developed as medications for asthma.
|
19426955 |
2009 |
|
Schizophrenia
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
We identified 4570 SNPs across the PDE4D gene, with 380 associated to schizophrenia (p ≤ 0.05).
|
31138891 |
2019 |
|
Schizophrenia
|
0.420 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies five new schizophrenia loci.
|
21926974 |
2011 |
|
Schizophrenia
|
0.420 |
Biomarker
|
disease |
PSYGENET |
Greater significance was observed with allelic haplotypes of PDE4D (p = .00084), PDE4B (p = .0022 and p = .029), and NDEL1 (p = .0027) that increased or decreased schizophrenia susceptibility.
|
19251251 |
2009 |
|
Schizophrenia
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
Greater significance was observed with allelic haplotypes of PDE4D (p = .00084), PDE4B (p = .0022 and p = .029), and NDEL1 (p = .0027) that increased or decreased schizophrenia susceptibility.
|
19251251 |
2009 |