|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no association between clinical severity and recurrence with variants rs2383207 (CDKN2B-AS1) for atherothrombotic IS and variants rs879324 (ZFHX3), rs966221 (PDE4D), and rs152312 (PDE4D) for cardioembolic IS.
|
31757599 |
2020 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These studies demonstrated levels of serum androgens, C-reactive protein, and advanced glycation endproducts; thrombin generation; left ventricular mass; depressive symptoms; phosphodiesterase 4D single nucleotide polymorphisms; coagulation factor XII gene; peak thrombus generation; and lower cognitive functioning were independent risk factors for ischemic stroke in older adults.
|
31127075 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between PDE4D polymorphism and ischemic stroke in young population.
|
31303835 |
2019 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulating evidences have shown that inhibition of PDE4 is beneficial for the functional recovery after cerebral ischemia; i. subtype D of PDE4 (PDE4D) is viewed as a risk factor for ischemic stroke; ii. inhibition of PDE4 enhances neurological behaviors, such as learning and memory, after stroke in rodents; iii.PDE4 inhibition increases dendritic density, synaptic plasticity and neurogenesis; iv. activation of cAMP/CREB signaling by PDE4 inhibition causes an endogenous increase of BDNF, which is a potent modulator of neuroplasticity; v. PDE4 inhibition is believed to restrict neuroinflammation during ischemic stroke.
|
30416389 |
2018 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our meta-analysis demonstrated that the SNP83 polymorphism in the PDE4D gene might contribute to IS susceptibility especially in Asian populations.
|
29234926 |
2018 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multivariable adjusted analysis demonstrated a statistically significant relationship between SNP 83 of PDE4D gene polymorphism and increasing odds of IS under the dominant model of inheritance (OR, 1.59; 95% CI, 1.02 to 2.50; p value = 0.04) after adjustment of potential confounding variables.
|
28562233 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis suggested that PDE4D SNP 87 constitutes an independent risk factor for IS development.
|
28587358 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hence, the evidence from this meta-analysis concluded that MTHFR (677C>T and 1298A>C), eNOS (+894G>T and VNTR), PDE4D SNP 83, ACE I/D, AGT 235M>T, PON1 192Q>R, and ApoE ε2ε3ε4 polymorphisms predispose individuals to ischemic stroke.
|
28760411 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multivariate regression analysis showed that SNP87 of PDE4D gene was associated with increased risk of unfavorable outcome after total ischemic stroke (OR = 1.47, 95%CI 1.12-1.93), as well as stroke due to large-artery atherosclerosis (OR = 1.49, 95%CI 1.04-2.11) and small-artery occlusion (OR = 1.76, 95%CI 1.05-2.96) under a recessive model.
|
28225001 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression model was used to examine the association between SNPs in PDE4D gene and IS risk.
|
28191858 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association between the PDE4D gene polymorphisms and young-onset IS in Chinese population.
|
23466835 |
2016 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association between PDE4D gene and ischemic stroke: recent advancements.
|
26004910 |
2016 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed nonsignificant association between PDE4D SNP56 and IS risk (T vs. A: OR=1.01, 95%CI=0.88-1.15, P=0.90).
|
27759001 |
2016 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
The phosphodiesterase 4D (PDE4D) gene has been reported as a risk gene for ischemic stroke.
|
26521189 |
2016 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Investigation of single nucleotide polymorphisms in phosphodiesterase 4D gene in Mongol and Han patients with ischemic stroke in Inner Mongolia.
|
26345966 |
2015 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the univariate analysis, the rs918592 polymorphism in PDE4D was found to be significantly associated with ischemic stroke with the recessive model (P = 0.02), whereas no association with ischemic stroke was observed for rs4075015 and rs4537545 in IL6R.
|
26782593 |
2015 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate the association between the risk of ischemic stroke and single-nucleotide polymorphisms (SNPs) in the ALOX5AP and PDE4D genes in a southeastern Chinese population.
|
24485247 |
2015 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke.
|
24365247 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PDE4D has been identified as a predisposition gene for ischemic stroke in Southern as well as the Northern population of India.
|
23135027 |
2013 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that SNP 83 in PDE4D gene is significantly associated with susceptibility to ischemic stroke in Chinese population.
|
23799094 |
2013 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene.
|
22274584 |
2012 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to investigate the possible association of genetic polymorphisms in PDE4D gene with IS in Henan Han population.
|
22882844 |
2012 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion PDE4D gene plays a key part in the pathogenesis of ischemic stroke in the South Indian population from Andhra Pradesh.
|
22771915 |
2012 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis revealed a significant association of PDE4D gene variants with the risk of ischemic stroke, and further investigations are warranted to evaluate possible ethnic-specific effects.
|
21677445 |
2011 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Aim Undertake a multivariate analysis of six single nucleotide polymorphisms within the phosphodiesterase 4D gene in a previously defined Australian stroke cohort, to determine whether these single nucleotide polymorphisms have an association with ischemic stroke.
|
21989204 |
2011 |