In addition, Prx1 and Prx2 are able to bind to a diversity of interaction partners to regulate other various cellular processes in cancer (i.e., regulation of the protein redox status, cell growth, apoptosis, and tumorigenesis).
Our findings suggest that Prx II has an important role in cancer cell survival via the modulation of signaling molecules involved in apoptosis and the phosphorylation of JNK by the downregulation of ROS levels in A549/GR cells.
Prx II was strongly expressed in mature endothelial cells of benign vascular tumors, whereas it was expressed weakly or not expressed in immature endothelial cells in malignant tumors of Kaposi's sarcoma and angiosarcoma.