|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, SIRT7 re-expression markedly enhanced thyroid cancer cell growth, invasiveness and tumorigenic potential in nude mice.
|
30093629 |
2019 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, Sirt7 may function as a valuable target for the treatment of human glioma.
|
30675198 |
2019 |
|
Mastitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, SIRT7 may be considered as a potential pharmacological target for clinical mastitis therapy.
|
31285783 |
2019 |
|
Skin lesion
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression levels of SIRT1, SIRT2, SIRT3, SIRT4 and SIRT5 were downregulated while those of SIRT6 and SIRT7 were upregulated in skin lesions and TNF‑α‑stimulated HaCaT cells compared with the control group as determined by RT‑qPCR, western blotting and IF.
|
31017270 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, SIRT7 re-expression markedly enhanced thyroid cancer cell growth, invasiveness and tumorigenic potential in nude mice.
|
30093629 |
2019 |
|
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we found that SIRT7 expression was elevated in papillary thyroid cancers (PTCs), and demonstrated that SIRT7 knockdown dramatically inhibited the proliferation, colony formation, migration and invasion of thyroid cancer cells, and induced thyroid cancer cell cycle arrest and apoptosis.
|
30093629 |
2019 |
|
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, SIRT7 re-expression markedly enhanced thyroid cancer cell growth, invasiveness and tumorigenic potential in nude mice.
|
30093629 |
2019 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SIRT6 and SIRT7 were overexpressed in ometal metastases compared with corresponding primary counterparts.
|
31113446 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, little is known about the role of SIRT7 in atherosclerosis.
|
30627559 |
2018 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrate that SIRT7 is involved in regulating TGF-β1-induced ASM cell proliferation and migration by regulating the expression of TβRI, thus indicating an important role of SIRT7 during airway remodeling in asthma.
|
29843083 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, little is known about the role of SIRT7 in atherosclerosis.
|
30627559 |
2018 |
|
Cartilage Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Although the roles of sirtuins in cartilage homeostasis and cartilage diseases have been well studied, there is no information on the contribution of SIRT7 to cartilage homeostasis and osteoarthritis (OA) pathologies.
|
29402405 |
2018 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we evaluated different roles of sirtuins (SIRT1-SIRT7) in diabetes progression and described their involvement in metabolic pathways of skeletal muscle, adipose tissue and liver.
|
30559718 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we evaluated different roles of sirtuins (SIRT1-SIRT7) in diabetes progression and described their involvement in metabolic pathways of skeletal muscle, adipose tissue and liver.
|
30559718 |
2018 |
|
Hemangiosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, our results showed that miR-340 negatively regulated SIRT7 expression in angiosarcoma cells and an inverse correlation between miR-340 and SIRT7 expression was shown in clinical angiosarcoma tissues.
|
29710664 |
2018 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicate that SIRT7 plays an important role in cisplatin-induced AKI and suggest the possibility of SIRT7 as a novel therapeutic target for cisplatin-induced nephrotoxicity.
|
29651144 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, our data suggest that SIRT7 is an essential factor in the determination of oocyte quality and may mediate the effects of obesity on female reproduction.-Gao, M., Li, X., He, Y., Han, L., Qiu, D., Ling, L., Liu, H., Liu, J., Gu, L. SIRT7 functions in redox homeostasis and cytoskeletal organization during oocyte maturation.
|
29879377 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicate that SIRT7 is a novel important regulator of cartilage homeostasis and OA development.
|
29402405 |
2018 |
|
Cicatrix, Hypertrophic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of SIRT7 abrogated the effects mediated by miR-519d overexpression in HS fibroblasts.
|
29428666 |
2018 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nevertheless, the clinical significance of SIRT7 and its role in cholangiocarcinoma (CCA) is largely undiscovered.
|
29438839 |
2018 |
|
Congenital contractural arachnodactyly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data further confirmed that SIRT7 was overexpressed in CCA patient tissues and cell lines.
|
29438839 |
2018 |
|
Adult Angiosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, our results showed that miR-340 negatively regulated SIRT7 expression in angiosarcoma cells and an inverse correlation between miR-340 and SIRT7 expression was shown in clinical angiosarcoma tissues.
|
29710664 |
2018 |
|
Childhood Angiosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, our results showed that miR-340 negatively regulated SIRT7 expression in angiosarcoma cells and an inverse correlation between miR-340 and SIRT7 expression was shown in clinical angiosarcoma tissues.
|
29710664 |
2018 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The sirtuin family comprises of seven members (Sirt1 to Sirt7), out of which Sirt1, Sirt3, Sirt6, and Sirt7 exert positive effects on IPF.
|
30390331 |
2018 |
|
Inflammatory cardiomyopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
A role of Sirt7, a related epigenetic regulator, on immune system regulation has been proposed before, as these mice are more susceptible to develop inflammatory cardiomyopathy.
|
28939414 |
2018 |