|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockout of SIRT7 reduced proliferation of HCC cells and growth of tumors in immune-deficient mice.
|
31678303 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIRT7 deacetylates its substrates histone H3 (at lysine 18) and p53. p53, a tumor suppressor, induces apoptosis or cell cycle arrest and is stabilized by acetylation. p53 deacetylation at K382 by SIRT7 suppressed cancer cell growth by attenuating p53 activity.
|
30503501 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Clinical analysis revealed that high SIRT7 expression was correlated with large tumor size and advanced tumor-node-metastasis (TNM) stage.
|
29438839 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It was demonstrated that Sirt7 presented a higher expression in CRC tissues and cell lines compared with that in normal tissues and cells, and this higher expression was correlated with the tumor size, the tumor, node and metastasis stage and distant metastasis.
|
29467843 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft model studies showed that stable silencing of SIRT7 inhibited tumor growth and enhanced tumor sensitivity to DOX.
|
29231244 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is still a controversy whether the role of Sirtuin 7 (SIRT7) is an oncogene or a tumor suppressor gene in cancer as SIRT7 may have different functions in different types of cancer.
|
28979804 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There is some evidence that SIRT7 may function as a tumor trigger for human malignancy.
|
25921180 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors.
|
25923013 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The Sirt7 protein level significantly correlated with tumor stage (P = 0.029), lymph node metastasis (P = 0.046), and poor patient survival (P < 0.05).
|
24771643 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It has been shown that SIRT7 regulates rDNA transcription and that reduced SIRT7 levels inhibit tumor growth.
|
24113281 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Through H3K18 deacetylation at specific promoters, SIRT7 controls a tumor-suppressive gene expression program that stabilizes the transformed state of cancer cells.
|
24536059 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, sustained suppression of SIRT7 reduced the in vivo tumor growth rate in a mouse xenograft model.
|
23079745 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, our work establishes SIRT7 as a highly selective H3K18Ac deacetylase and demonstrates a pivotal role for SIRT7 in chromatin regulation, cellular transformation programs and tumour formation in vivo.
|
22722849 |
2012 |