SIRT7, sirtuin 7, 51547

N. diseases: 80; N. variants: 0
Disease: Steatohepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.310 Biomarker disease BEFREE Recently, we found that Sirt7 knockout mice are resistant to high-fat diet-induced fatty liver, and that SIRT7 positively regulates the protein level of TR4, a nuclear receptor involved in lipid metabolism, by inhibiting the CUL4B/DDB1/DCAF1 E3 ubiquitin ligase complex. 28623141 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.310 Biomarker disease CTD_human Myc inactivation or pharmacological suppression of ER stress alleviates fatty liver caused by SIRT7 deficiency. 24210820 2013