|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results identified cancer-associated point mutations in SIRT6, cementing its function as a tumor suppressor in human cancer.
|
26456828 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Sirtuin 6 (SIRT6) can function as a tumor suppressor by suppressing aerobic glycolysis and apoptosis resistance.
|
25683165 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The NAD-dependent histone deacetylase, SIRT6, a known tumor suppressor, was a critical regulator of these RUNX2-mediated metabolic changes.
|
25808624 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In summary, our findings implicate that SIRT6 inhibits PCBP2 expression through deacetylating H3K9ac and SIRT6 acts as a tumor suppressor in human glioma.
|
24607900 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Sirtuin 6 (SIRT6) is associated with longevity and is also a tumor suppressor.
|
25074979 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Recently, the sirtuin SIRT6 has been shown to inhibit the transcriptional output of both HIF1 and MYC, and to function as a tumor suppressor.
|
25085992 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Despite of its proposed tumor suppressor role, no significant differences in SIRT6 mRNA levels among normal bladder urothelium, non-muscle invasive, and muscle invasive urothelial carcinoma were noted in the two largest bladder cancer gene expression datasets available in Oncomine.
|
25400728 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, these data suggest that Sirt6 is a tumor suppressor in HCC cells and may be a promising therapeutic target in HCC.
|
24366394 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It has been proposed previously that SIRT6 is a tumor suppressor in cancer.
|
25320180 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we demonstrated that the Sirt6-KO signature possessed a predictive value for tumors other than HCC (e.g., breast and lung cancer).
|
23526469 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Multivariate Cox analysis demonstrated that nuclear SIRT6 staining remained associated with death after correcting for tumour stage and lymph-node involvement (P = 0.033).
|
23514751 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently SIRT6 has been identified as a tumor suppressor and is down-regulated in certain cancer types, but not in other cancers.
|
23982738 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study discovered crosstalk between two tumor-suppressive genes in regulating cell-cycle progression and proliferation and showed that dysregulated USP10 function promotes tumorigenesis through SIRT6 degradation.
|
24332849 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
By using a conditional SIRT6 allele, we show that SIRT6 deletion in vivo increases the number, size, and aggressiveness of tumors.
|
23217706 |
2012 |