Glioblastoma
|
0.400 |
CausalMutation
|
disease |
CGI |
|
|
|
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A common theme in glioblastoma is the amplification of genes that code for growth factor receptors of the protein-tyrosine kinase family (epidermal growth factor receptor, platelet-derived growth factor receptor-alpha, met).
|
7654823 |
1995 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The association of PDGFR-alpha expression with a distinct subset of glioblastomas characterized by loss of heterozygosity 17p further supports the differentiation of these tumors into molecular variants.
|
8548759 |
1996 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overexpression of PDGF system components, particularly the alpha subtype receptor (PDGFRA), is common in glial tumors, and PDGFRA gene amplification has been reported in glioblastomas.
|
10850862 |
2000 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Four glioblastomas showed markedly increased PDGFRA mRNA expression due to PDGFRA gene amplification.
|
14730454 |
2004 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
KIT was amplified in 47% and VEGFR2 in 39% of the glioblastomas, respectively, and PDGFRA in 29%.
|
16021678 |
2005 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas.
|
16186508 |
2005 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme.
|
15831234 |
2005 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also detected amplifications of epidermal growth factor receptor (EGFR) or platelet-derived growth factor receptor alpha (PDGFRalpha) in a few of the 13 cases of glioblastoma multiforme analyzed.
|
17145861 |
2006 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Haplotype-specific expression of the human PDGFRA gene correlates with the risk of glioblastomas.
|
18464291 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Phosphorylated receptor tyrosine kinase profiling showed a specific activation of platelet-derived growth factor receptor alpha/beta in EGFRvIII-transduced pediatric glioblastoma cells, and targeted coinhibition with erlotinib and imatinib leads to enhanced efficacy in this model.
|
19737945 |
2009 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The PDGFRA(Δ8, 9) mutant was common, being present in 40% of the glioblastoma multiformes (GBMs) with PDGFRA amplification.
|
20889717 |
2010 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although it is known that oncogenic signaling caused by overexpression of genes such as PDGFRA is responsible for robust glioma growth and cell infiltration, the mechanisms underlying glioblastoma malignancy remain largely elusive.
|
22080864 |
2011 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
No significant difference was observed in the frequency of amplification of these genes in primary and secondary glioblastomas or in glioblastomas with and without IDH1 mutations, suggesting that amplification of PDGFRA, KIT and KDR may be implicated in the pathogenesis of a small fraction of both subtypes of glioblastoma.
|
21382095 |
2011 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response.
|
22323597 |
2012 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that PDGFRα is expressed only in a subset of GBMs, while PDGFRβ is more commonly expressed in tumors but is preferentially expressed by self-renewing tumorigenic GBM stem cells (GSCs).
|
22661233 |
2012 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, this study identifies Dyn2 as an effector that mediates PDGFRα-SHP-2-induced glioma tumor growth and invasion, suggesting that targeting the PDGFRα-SHP-2-Dyn2 pathway may be beneficial to patients with malignant glioblastomas.
|
21996738 |
2012 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, PDGFRA has been recently shown to be rearranged in glioblastoma.
|
23074200 |
2012 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A younger age at diagnosis and better clinical outcome in glioblastoma patients is only seen when PDGFRA and KIT are co-amplified.
|
23990986 |
2013 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We showed that machine-based classification of GBMs with high oligodendroglioma component uncovered a set of tumors with strong associations with PDGFRA amplification, proneural transcriptional class, and expression of the oligodendrocyte signature genes MBP, HOXD1, PLP1, MOBP and PDGFRA.
|
24236209 |
2013 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Glioblastomas with a proneural expression signature are characterized by frequent IDH1 mutations (i.e. genetic hallmarks of secondary glioblastomas) and PDGFRA (platelet-derived growth factor receptor-α) amplification.
|
23242283 |
2013 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.
|
23438035 |
2013 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The extrachromosomal nature of ALEMs explains the observed drastic changes in the amounts of mutated oncogenes (like EGFR or PDGFRA) in glioblastoma in response to environmental changes.
|
25471132 |
2014 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We find evidence of regional mutational heterogeneity in multiple tumors, including mutations in TP53 and RB1 in an anaplastic oligodendroglioma and amplifications in PDGFRA and KIT in two glioblastomas (GBMs).
|
25608559 |
2014 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, forced expression of miR-129-2 repressed the expression of major oncogenic genes such as PDGFRa and Foxp1 in GBMs.
|
26320507 |
2015 |