Arthritis, Psoriatic
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Anti-cyclic citrullinated peptide antibodies and IL-23p19 in psoriatic arthritis.
|
18752933 |
2009 |
Arthritis, Psoriatic
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Association of interleukin 23 receptor variants with psoriatic arthritis.
|
19040306 |
2009 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
More recently, analysis of psoriasis genome-wide association studies in a PsA subgroup has also implicated IL23A, TNFAIP3, and TNIP1 genetic variants as conferring risk to PsA.
|
20875338 |
2010 |
Arthritis, Psoriatic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis.
|
21623003 |
2011 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest a role of the IL-17/IL-23 cytokine axis in synovial LN in PsA.
|
22541888 |
2012 |
Arthritis, Psoriatic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We confirm the previously described association of rs2066808 variant with psoriasis and PsA and we show evidence of an extended genomic region inside IL23A gene as carrier of true disease susceptibility factors.
|
23673284 |
2013 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus.
|
24957500 |
2014 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Psoriatic arthritis (PsA) can be treated using biologic therapies targeting biomolecules such as tumor necrosis factor alpha, interleukins (IL)-17 and IL-23.
|
26108918 |
2016 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Biological DMARDs (bDMARDs) targeting cytokines IL-12/IL-23, TNF and IL-17 involved in the pathogenesis of PsA, have been emerging for the treatment.
|
27586804 |
2016 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-23/IL-17 axis plays a critical pathogenic role for both PsA and Ps, and biologics neutralizing IL-17A or IL-23/IL-12 are effective therapies for PsA and Ps.
|
27666819 |
2017 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cytokines interleukin (IL)-12 and IL-23 have been involved in the pathogenesis of psoriasis and psoriatic arthritis.
|
28441904 |
2017 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, polymorphisms of <i>IL23R</i> are a risk factor for ankylosing spondylitis (AS) and psoriatic arthritis (PsA), which indicates that IL-23 is also involved in the pathogenesis of spondyloarthritis (SpA).
|
28850053 |
2017 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-23/Th17 axis has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
|
29148561 |
2018 |
Arthritis, Psoriatic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the study, a higher level of IL-17 and IL-23 was also shown in patients with psoriatic arthritis in comparison to patients with normal psoriasis.
|
30206447 |
2018 |
Arthritis, Psoriatic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study we show that psoriatic arthritis (PsA), a severe disease of the joints depending on the activation of the IL-23/IL-17 pathway, is characterized by a skewed ILC homeostasis.
|
29330320 |
2018 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis.
|
30172115 |
2018 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Perturbation of the IL-23/Th17 axis instigates Th17-mediated inflammation in R26Stat3C<sup>stopfl/fl</sup> CD4Cre mice, leading to cutaneous and synovio-entheseal inflammation and bone pathologic features highly reminiscent of human PsA.
|
29439292 |
2018 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-23/IL-17 axis is central to the pathogenesis of psoriatic arthritis (PsA).
|
29148410 |
2018 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The unique bone phenotype that occurs in PsA and AS is a surprising coexistence of both systemic bone loss and periosteal and entheseal bone formation and is likely to be the result of the actions of IL-23 and/or IL-17 on bone.
|
30266977 |
2018 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-23 is important in the proliferation and maintenance of IL-17, and therefore, cytokines of the IL-23/IL-17 axis attracted much interest as therapeutic targets in psoriasis and PsA.
|
31447673 |
2019 |
Arthritis, Psoriatic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), -308 G > A (rs1800629), and -857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026).
|
30584776 |
2019 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical trials have reported the effectiveness of numerous biologics with different targets, such as tumor necrosis factor-α, interleukin (IL)-17A, IL-17 receptor, IL-12/23(p40), and IL-23(p19) for the treatment of PsA.
|
30891646 |
2019 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the levels of the proinflammatory cytokines tumor necrosis factor α (TNF-α), interleukin 23 (IL-23) and IL-17 in patients with psoriasis and psoriatic arthritis with concomitant metabolic syndrome.
|
30858782 |
2019 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, these Ad.scIL-23-treated mice represent a physiologically relevant model of psoriatic arthritis for understanding disease progression and for testing therapeutic approaches.-Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., Evans, C. H., Gambotto, A., Niedernhofer, L. J., Robbins, P. D. Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.
|
31170010 |
2019 |
Arthritis, Psoriatic
|
0.100 |
Biomarker
|
disease |
BEFREE |
In recent years, interleukin (IL)-12/IL-23 inhibitors have entered clinical practice as a new class of drug for the treatment of PsA, with some data suggesting a lower effect of body weight on their effectiveness.
|
31264033 |
2019 |