|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors，including interleukin (IL)-1β, IL-6, tumour necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2), IL-17 and IL-23.
|
30743203 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Disease pathogenesis was driven by the IL-23/IL-17 axis, and neutralization of IL-23p19, the key cytokine in maintaining T helper type 17 cell polarization, significantly reduced skin lesions and the expression of antimicrobial peptides and proinflammatory cytokines.
|
29689250 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Assessment of the concentration of the proinflammatory cytokines (IL-12, IL-23, IL-17 and TNF-α) in blood serum and their correlation with the intensity of skin lesions, the presence of psoriatic arthritis and the risk of development of obesity and metabolic syndrome.
|
30206447 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AKBA also obviously decreased the PASI score, reduced the thickness of epidermis, ameliorated the infiltration of CD3+ and CD11c+ cells in skin lesions, decreased the activation of local DCs, inhibited the mRNA expression and secretion of inflammatory factors IL-12 and IL-23, inhibited the maturation and differentiation of DCs to promote T-cell differentiation, and inhibited the activation of TLR7/8 and IRF signaling pathways.
|
29859222 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Under the regulation of IL-23, T cells that produce high levels of IL-17 create a self-amplifying, feed-forward inflammatory response in keratinocytes that drives the development of thickened skin lesions infiltrated with a mixture of inflammatory cell populations.
|
30181299 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously identified 6-sulfo LacNAc-expressing monocytes (slanMo) as TNF-α- and IL-23-producing cells in psoriatic skin lesions and as inducers of IFN-γ-, IL-17-, and IL-22-producing T cells.
|
29977237 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Inflammatory cytokines [interleukin (IL)-23, IL-12 and IL-1β] in skin lesions and BMDCs were also assessed by RT-PCR and ELISA.
|
28339016 |
2017 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Besides, alkannin treatment decreased the expression of IL-23 in skin lesion.
|
26261548 |
2015 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We observed IL23p19 expression within skin lesions associated with exacerbated IL17A and IL22 production by infiltrating γδ T cells and draining lymph node CD4 T cells.
|
23940256 |
2013 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased IL-23 p19 mRNA levels were observed for both EN-like lesions of patients with BD and skin lesions of patients with psoriasis compared with normal individuals.
|
18205865 |
2008 |