Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Platelet-derived growth factor receptor β (PDGFRβ) is an established mesenchymal/stem cell-specific marker in human glioblastoma and, as recently suggested, it may uniquely mark breast cancer cells with stem-like characteristics and/or that have undergone epithelial-mesenchymal transition.
|
30429893 |
2018 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As indicated by our results, the TAM receptors, Trk receptors and PDGFRs need to be investigated further since their regulation appears to be important for glioblastoma biological features as well as the clinical course of the disease.
|
24270553 |
2014 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients.
|
23533263 |
2013 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of PDGFRB and EGFR in microvascular proliferation in glioblastoma.
|
26857280 |
2016 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.
|
24023874 |
2013 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we analyzed the effect of AG1433 (a PDGFR inhibitor), SU1498 (a VEGFR inhibitor) and BEZ235 (a PI3K/Akt/mTOR signaling pathways inhibitor) on glioblastoma cells in vitro.
|
26339347 |
2015 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we quantified RNA expression levels of stem cell markers [CD133, Nestin, BMI-1, maternal embryonic leucine zipper kinase (MELK), and Notch1-4] as well as RTKs (EGFR, ErbB4, VEGFR1-3, FGFR1, -2, PDGFRΑ, and PDGFRΒ) in 42 clinical samples of glioblastoma by the real-time RT-PCR method.
|
21691733 |
2011 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One glioblastoma showed PDGFR A amplification, while no amplifications were observed for mdm2 and CDK4 genes.
|
12241104 |
2002 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggested that PDGFR-β may be used as a target for the radiosensitization of glioblastoma.
|
28693172 |
2017 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, we revealed that PDGFRβ accumulation is associated with increased oxidative stress and cellular damage in SESN2 silenced human glioblastoma U87 cells.
|
21536039 |
2011 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This aptamer is able to specifically bind to the human PDGFRβ ectodomain (Kd: 9.6 nmol/l) causing a strong inhibition of ligand-dependent receptor activation and of downstream signaling in cell lines and primary cultures of human glioblastoma cells.
|
24566984 |
2014 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have studied the effects of the PDGFR inhibitor JNJ-10198409 (JNJ) and the IGF-1R inhibitor picropodophyllin (PPP) in glioblastoma cell lines as well as in primary cultures derived from patients affected by this type of tumor.
|
30200644 |
2018 |