Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that Aβ-mediated reduction of ATP synthase activity in AD pathology results from direct binding between Aβ and ATP synthase and inhibition of O-GlcNAcylation of Thr432 residue on ATP5A.
|
26358770 |
2015 |
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, the expression of a number of genes related to meiosis (Inhibitor Of DNA Binding 2 (ID2), Ovo Like Transcriptional Repressor 1 (OVOL1)), mitochondria (ATP1b (ATPase Na+/K+ Transporting Subunit Beta 1), ATP2a (ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2), ATP5a (ATP Synthase F1 Subunit Alpha), Mitochondrially Encoded Cytochrome C Oxidase I (COX1), NADH Dehydrogenase Subunit 4 (ND4)) and chromatin structure (Histone 1 (H1), Histone 2a (H2A), Histone 2b (H2B), Histone 3 (H3), Histone 4 (H4)) was lower in the testes of 3nBY, whereas the expression of genes encoding ubiquitin (Ubiquitin Conjugating Enzymes (UBEs), Ring Finger Proteins (RNFs)) and apoptosis (CASPs (Caspase 3, Caspase 7,Caspase 8), BCLs (B-Cell Lymphoma 3, B-Cell CLL/Lymphoma 2, B Cell CLL/Lymphoma 10)) proteins involved in spermatid degeneration was higher.
|
30086823 |
2019 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed that altered expression of ATPAF1 and ATP5G1/G2/G3 was correlated with overall survival in patients with ccRCC.
|
28672194 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A further integration of DNA methylation (n = 1980) and epigenomic annotation data highlight 3 genes (CAMK1D, TP53INP1, and ATP5G1) with plausible regulatory mechanisms, whereby a genetic variant exerts an effect on T2D through epigenetic regulation of gene expression.
|
30054458 |
2018 |
Juvenile Neuronal Ceroid Lipofuscinosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Abnormal degradative pathway of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid-lipofuscinosis (Batten disease).
|
7668341 |
1995 |
Juvenile Neuronal Ceroid Lipofuscinosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Specific delay of degradation of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid lipofuscinosis (Batten disease).
|
7830067 |
1995 |
Juvenile Neuronal Ceroid Lipofuscinosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Variant late-infantile neuronal ceroid lipofuscinosis (vLINCL), caused by CLN6 mutation, and juvenile neuronal ceroid lipofuscinosis (JNCL), caused by CLN3 mutation, share clinical and pathological features, including lysosomal accumulation of mitochondrial ATP synthase subunit c, but the unrelated CLN6 and CLN3 genes may initiate disease via similar or distinct cellular processes.
|
21359198 |
2011 |
Late-Infantile Neuronal Ceroid Lipfuscinosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Abnormal degradative pathway of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid-lipofuscinosis (Batten disease).
|
7668341 |
1995 |
Late-Infantile Neuronal Ceroid Lipfuscinosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Specific delay of degradation of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid lipofuscinosis (Batten disease).
|
7830067 |
1995 |
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The neuronal ceroid-lipofuscinosis (NCL) are a heterogeneous group of neurodegenerative diseases characterized by the lysosomal accumulation of ceroid and lipofuscin with mitochondrial ATP synthase subunit C in various tissues.
|
23180398 |
2013 |
Neuronal Ceroid-Lipofuscinoses
|
0.030 |
Biomarker
|
disease |
BEFREE |
The neuronal ceroid-lipofuscinosis (NCL) are a heterogeneous group of neurodegenerative diseases characterized by the lysosomal accumulation of ceroid and lipofuscin with mitochondrial ATP synthase subunit C in various tissues.
|
23180398 |
2013 |
Neuronal Ceroid-Lipofuscinoses
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
Lysine methylation of mitochondrial ATP synthase subunit c stored in tissues of dogs with hereditary ceroid lipofuscinosis.
|
8144584 |
1994 |
Neuronal Ceroid-Lipofuscinoses
|
0.030 |
Biomarker
|
disease |
BEFREE |
Mitochondrial ATP synthase subunit c stored in hereditary ceroid-lipofuscinosis contains trimethyl-lysine.
|
7575423 |
1995 |
Squamous cell carcinoma of the head and neck
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blot analyses of the several stage IVA HNSCC primary tumors have shown reduction in the expression of COII and ATP5A of the OXPHOS complexes IV and V subunits, respectively.
|
26238294 |
2015 |