|
Adult type dermatomyositis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Some recent data have indicated that it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis; however, studies on the prevalence and clinical characteristics of pruritus in CLE are limited.
|
30148164 |
2018 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which 70% of patients experience disfiguring skin inflammation (grouped under the rubric of cutaneous lupus erythematosus [CLE]).
|
30745462 |
2019 |
|
Barrett Esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
The spacer sequence between the palindromic motifs is constant in length, but its sequence is highly variable among viral species, presenting a relaxed consensus (TT)GGKCCCY, which is similar to the Conserved Late Element or CLE (GTGGTCCC), a putative TrAP-responsive element.
|
30673741 |
2019 |
|
Barrett Esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
The frequency of GIN, methylation at E-cadherin and APC, and mAb Das-1 reactivity in Group BE was significantly higher than that in Group CLE (p < 0.0001, p < 0.0001 and p < 0.005, and p < 0.0001, respectively).
|
19048617 |
2009 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that C14orf166 promotes bladder cancer cell proliferation and can be a novel prognostic biomarker for patients with bladder cancer.
|
26905879 |
2016 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, CGI-99 was highly expressed in all brain tumors which is in agreement with the Northern blot analysis.
|
15147888 |
2004 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
C14orf166 overexpression promoted breast cancer cell proliferation, whereas knockdown of C14orf166 inhibited this effect.
|
26883017 |
2016 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Finally, we find that high levels of CGI-99 are significantly correlated with STAT3 hyperactivation in breast cancer patients.
|
28166202 |
2017 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
CLE-10 from <i>Carpesium abrotanoides</i> L. Suppresses the Growth of Human Breast Cancer Cells (MDA-MB-231) In Vitro by Inducing Apoptosis and Pro-Death Autophagy Via the PI3K/Akt/mTOR Signaling Pathway.
|
30897708 |
2019 |
|
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Two epithelial cell lines, HCLE and HK2, have both higher concentrations of GLUT1 and increased basal 2DG uptake (3-4 fold) compared to L929 cells, and subsequently display greater maximal inhibition by caffeine (66-70%).
|
28322926 |
2017 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Taken together, we have isolated a novel protein CGI-99, which may be involved in the functional regulation of human ninein in the centrosome structure and may also be important in brain development and tumorigenesis.
|
15147888 |
2004 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
C14orf166, a 28 kD protein regulating RNA transcription and translation, may serve a critical role in oncogenesis.
|
28000881 |
2017 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Chromosome 14 ORF 166 (C14orf166), a protein involved in the regulation of RNA transcription and translation, has been reported to possess the potency to promote tumorigenesis; however, the role of C14orf166 in non-small-cell lung cancer (NSCLC) remains unknown.
|
30126850 |
2018 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that C14orf166 promotes bladder cancer cell proliferation and can be a novel prognostic biomarker for patients with bladder cancer.
|
26905879 |
2016 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multiple blinded raters validated CLE videos of lung tumours and mediastinal nodes twice.EUS-nCLE-FNA was performed in 22 patients with suspected or proven lung cancer in whom 27 lesions (six tumours, 21 mediastinal nodes) were evaluated without complications.
|
31023849 |
2019 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the expression and clinicopathological significance of C14ORF166 in cervical cancer.
|
26219895 |
2016 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the expression and clinicopathological significance of C14ORF166 in cervical cancer.
|
26219895 |
2016 |
|
Chilblains
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The highest mean pruritus intensity was reported by subjects with hypertrophic LE (5.1 ± 3.0 points) followed by generalized discoid LE (3.6 ± 3.0 points), subacute CLE (3.0 ± 3.0 points), chilblain LE (3.0 ± 1.0 points), localized discoid LE (2.6 ± 2.0 points), intermittent CLE (2.6 ± 3.0 points), acute CLE (2.5 ± 1.2 points), and lupus erythematosus profundus (1.9 ± 2.7 points).
|
30148164 |
2018 |
|
Childhood Ataxia with Central Nervous System Hypomyelinization
|
0.010 |
Biomarker
|
disease |
BEFREE |
The spacer sequence between the palindromic motifs is constant in length, but its sequence is highly variable among viral species, presenting a relaxed consensus (TT)GGKCCCY, which is similar to the Conserved Late Element or CLE (GTGGTCCC), a putative TrAP-responsive element.
|
30673741 |
2019 |
|
Congenital emphysema
|
0.010 |
Biomarker
|
disease |
BEFREE |
The spacer sequence between the palindromic motifs is constant in length, but its sequence is highly variable among viral species, presenting a relaxed consensus (TT)GGKCCCY, which is similar to the Conserved Late Element or CLE (GTGGTCCC), a putative TrAP-responsive element.
|
30673741 |
2019 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, acute CLE and HIIE did not stimulate significant HPC mobilisation in CHD, although both exercise modes elevated circulating concentrations of sympathetic activation.
|
29933914 |
2019 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aims of this pilot study performed in patients with CD after ileocolonic resection were to compare the macroscopic appearance of the neoterminal ileum, according to the endoscopic Rutgeerts score, with the microscopic findings provided by CLE 6 to 12 months after surgery and to assess the predictive values of CLE-generated parameters for predicting further recurrence in patients with postoperative endoscopic remission.
|
30849396 |
2019 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which 70% of patients experience disfiguring skin inflammation (grouped under the rubric of cutaneous lupus erythematosus [CLE]).
|
30745462 |
2019 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results demonstrate that ruxolitinib significantly decreases the production of CLE-typical cytokines (CXCL10, CXCL9, MxA) and might be a promising drug for future clinical studies in patients with CLE and related autoimmune skin diseases.
|
27892610 |
2017 |
|
Dermatomyositis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Some recent data have indicated that it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis; however, studies on the prevalence and clinical characteristics of pruritus in CLE are limited.
|
30148164 |
2018 |