Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Further investigations showed that activation of STAT3 was required for TPPP3-mediated upregulation of Twist1, cell migration and invasion.
|
30404076 |
2018 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Further experiments showed that knockdown of TPPP3 inhibited cell proliferation, migration and invasion and induced cell apoptosis in vitro.
|
28819371 |
2017 |
Muscular Dystrophy, Duchenne
|
0.020 |
Biomarker
|
disease |
BEFREE |
Identification of Duchenne muscular dystrophy genomic probe P20 constant Taql fragment corresponding to the EcoRV and Mspl polymorphisms.
|
1709287 |
1991 |
Muscular Dystrophy, Duchenne
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, these properties make P20 useful for carrier detection, prenatal diagnosis, and the study of deletion induction in both DMD and BMD.
|
2900805 |
1988 |
Fibrosis, Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, NLRP6<sup>-</sup><sup>/</sup><sup>-</sup> mice showed more severe liver damage and liver fibrosis after transplantation together with higher level of phosphorylated Iκbα, phosphorylated p38-MAPK, Pro-caspase-1, p20 expression as well as IL-1β, IL-18, IL-6, and TNF-α secretion compared with wide-type.
|
31301646 |
2019 |
Hypoalbuminemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the 14 patients with severe kidney dysfunction and hypoalbuminemia, none of the coefficients had a P20 accuracy greater than 45%.
|
31067355 |
2019 |
Sarcoma
|
0.010 |
Biomarker
|
group |
BEFREE |
We identify Tppp3-expressing cells in peripheral nerves as a cell-of-origin for these sarcomas.
|
31488818 |
2019 |
Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD.
|
29735977 |
2019 |
Malignant neoplasm of soft tissue
|
0.010 |
Biomarker
|
group |
BEFREE |
We identify Tppp3-expressing cells in peripheral nerves as a cell-of-origin for these sarcomas.
|
31488818 |
2019 |
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, overexpression of TPPP3 remarkably promoted NSCLC cell migration and invasion along with the upregulation of Twist1 both in vitro and in vivo.
|
30404076 |
2018 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In the present study, upregulation of TPPP3 was found to correlate with an increased metastasis capability of NSCLC.
|
30404076 |
2018 |
early pregnancy
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our study suggests that TPPP3 is important for embryo implantation and for the establishment of early pregnancy through modulation of β-catenin.
|
29901777 |
2018 |
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Little is known about the function of TPPP3 in tumor metastasis.
|
30404076 |
2018 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, our results suggested that TPPP3 played an important role in CRC progress and might serve as novel therapeutic target for CRC treatment.
|
28819371 |
2017 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Additionally to the better tumor targeting and the in situ release of P20, it is expected that the therapeutic efficiency of the dual-peptide PLGA NPs was further enhanced by a synergistic effect between P20 and combined peptide C. Our encouraging results showed that by enabling the co-delivery of two peptides and promoting tumor targeting, PLGA NPs coupled with peptide C is a promising platform for peptide-based cancer therapy.
|
28547860 |
2017 |
Photoreceptor degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Reep6-/- mice exhibited progressive photoreceptor degeneration from P20 onwards.
|
28475715 |
2017 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 inhibits cell proliferation and invasion in human colorectal cancer.
|
28819371 |
2017 |
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
We demonstrate that systemically delivered and CNS-restricted rAAVs can serve as efficacious and sustained gene therapeutics in a model of a severe neurodegenerative disorder even when administered as late as P20.
|
23817205 |
2013 |
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
While treatment with TRAIL alone caused partial processing of caspase-3 to its p20 intermediate in TRAIL-resistant glioma cell lines, co-treatment with TRAIL and subtoxic doses of paxilline caused complete processing of caspase-3 into its active subunits.
|
21150246 |
2011 |
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells.
|
21801775 |
2011 |
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells.
|
21801775 |
2011 |
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells.
|
21801775 |
2011 |
Schizophrenia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
|
19165527 |
2009 |
Becker Muscular Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these properties make P20 useful for carrier detection, prenatal diagnosis, and the study of deletion induction in both DMD and BMD.
|
2900805 |
1988 |