Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.020 AlteredExpression phenotype BEFREE Further investigations showed that activation of STAT3 was required for TPPP3-mediated upregulation of Twist1, cell migration and invasion. 30404076 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.020 Biomarker phenotype BEFREE Further experiments showed that knockdown of TPPP3 inhibited cell proliferation, migration and invasion and induced cell apoptosis in vitro. 28819371 2017
CUI: C0013264
Disease: Muscular Dystrophy, Duchenne
Muscular Dystrophy, Duchenne
0.020 Biomarker disease BEFREE Identification of Duchenne muscular dystrophy genomic probe P20 constant Taql fragment corresponding to the EcoRV and Mspl polymorphisms. 1709287 1991
CUI: C0013264
Disease: Muscular Dystrophy, Duchenne
Muscular Dystrophy, Duchenne
0.020 Biomarker disease BEFREE Together, these properties make P20 useful for carrier detection, prenatal diagnosis, and the study of deletion induction in both DMD and BMD. 2900805 1988
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.010 AlteredExpression disease BEFREE However, NLRP6<sup>-</sup><sup>/</sup><sup>-</sup> mice showed more severe liver damage and liver fibrosis after transplantation together with higher level of phosphorylated Iκbα, phosphorylated p38-MAPK, Pro-caspase-1, p20 expression as well as IL-1β, IL-18, IL-6, and TNF-α secretion compared with wide-type. 31301646 2019
CUI: C0239981
Disease: Hypoalbuminemia
Hypoalbuminemia
0.010 Biomarker disease BEFREE In the 14 patients with severe kidney dysfunction and hypoalbuminemia, none of the coefficients had a P20 accuracy greater than 45%. 31067355 2019
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.010 Biomarker group BEFREE We identify Tppp3-expressing cells in peripheral nerves as a cell-of-origin for these sarcomas. 31488818 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.010 AlteredExpression disease BEFREE Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD. 29735977 2019
CUI: C4551686
Disease: Malignant neoplasm of soft tissue
Malignant neoplasm of soft tissue
0.010 Biomarker group BEFREE We identify Tppp3-expressing cells in peripheral nerves as a cell-of-origin for these sarcomas. 31488818 2019
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.010 AlteredExpression disease BEFREE Furthermore, overexpression of TPPP3 remarkably promoted NSCLC cell migration and invasion along with the upregulation of Twist1 both in vitro and in vivo. 30404076 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 AlteredExpression phenotype BEFREE In the present study, upregulation of TPPP3 was found to correlate with an increased metastasis capability of NSCLC. 30404076 2018
CUI: C0747845
Disease: early pregnancy
early pregnancy
0.010 Biomarker phenotype BEFREE In conclusion, our study suggests that TPPP3 is important for embryo implantation and for the establishment of early pregnancy through modulation of β-catenin. 29901777 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.010 Biomarker group BEFREE Little is known about the function of TPPP3 in tumor metastasis. 30404076 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker disease BEFREE Thus, our results suggested that TPPP3 played an important role in CRC progress and might serve as novel therapeutic target for CRC treatment. 28819371 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 Biomarker group BEFREE Additionally to the better tumor targeting and the in situ release of P20, it is expected that the therapeutic efficiency of the dual-peptide PLGA NPs was further enhanced by a synergistic effect between P20 and combined peptide C. Our encouraging results showed that by enabling the co-delivery of two peptides and promoting tumor targeting, PLGA NPs coupled with peptide C is a promising platform for peptide-based cancer therapy. 28547860 2017
CUI: C1998028
Disease: Photoreceptor degeneration
Photoreceptor degeneration
0.010 Biomarker disease BEFREE The Reep6-/- mice exhibited progressive photoreceptor degeneration from P20 onwards. 28475715 2017
Malignant neoplasm of colon and/or rectum
0.010 Biomarker disease BEFREE Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 inhibits cell proliferation and invasion in human colorectal cancer. 28819371 2017
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders
0.010 Biomarker group BEFREE We demonstrate that systemically delivered and CNS-restricted rAAVs can serve as efficacious and sustained gene therapeutics in a model of a severe neurodegenerative disorder even when administered as late as P20. 23817205 2013
CUI: C0017638
Disease: Glioma
Glioma
0.010 Biomarker disease BEFREE While treatment with TRAIL alone caused partial processing of caspase-3 to its p20 intermediate in TRAIL-resistant glioma cell lines, co-treatment with TRAIL and subtoxic doses of paxilline caused complete processing of caspase-3 into its active subunits. 21150246 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.010 AlteredExpression disease BEFREE Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells. 21801775 2011
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.010 AlteredExpression disease BEFREE Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells. 21801775 2011
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.010 AlteredExpression disease BEFREE Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells. 21801775 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.010 AlteredExpression disease LHGDN Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. 19165527 2009
CUI: C0917713
Disease: Becker Muscular Dystrophy
Becker Muscular Dystrophy
0.010 Biomarker disease BEFREE Together, these properties make P20 useful for carrier detection, prenatal diagnosis, and the study of deletion induction in both DMD and BMD. 2900805 1988