Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 AlteredExpression group BEFREE In conclusion, the occurrence and progression of the thyroid carcinoma were related to the high expression of the PDK-1 and the low expression of the DMBT1 in the thyroid carcinoma tissues, the two of which were in connection with factors involving lymph node metastasis, pathological type, neoplasm staging, and clinical staging. 31452760 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE A xenograft tumour mouse model was used to determine the effect of pharmacological inhibition of PDK1 on PDAC cells growth in vivo. 31088502 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE The nanobubbles can also reprogram several hypoxia associated and tumor suppressor genes such as MAT2A and PDK-1, in addition to serving as an ultrasound contrast agent. 28839175 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE Bioinformatic analysis predicted 3-phosphoinositide-dependent protein kinase-1 (PDK1) as a target of miR-454 which acted as a tumor promoter gene. 26297548 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 AlteredExpression group BEFREE In addition, miR-138 downregulation and PDK1 upregulation were both significantly associated with advanced tumor-node-metastasis (TNM) stage (both P = 0.002) and positive lymph node metastasis (both P = 0.01) of NSCLC patients. 25064732 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 AlteredExpression group BEFREE In addition, high PDK1 expression was found to be closely correlated with advanced tumor stage (P = 0.006), positive lymph node metastasis (P = 0.01) and high histological grade (P = 0.02). 25416048 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE In fact, PDK1 silencing leads to increased anoikis, reduced soft agar growth, and pronounced apoptosis inside tumors. 22952425 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE In severe combined immunodeficiency mice, PDK1-depleted human breast cancer cells formed more slowly growing tumors and were defective in extravasation to mouse lungs after i.v. injection. 19531564 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE Small-molecule inhibitory agents that blocked stimulated and/or basal PDK-1 and AKT function profoundly reduced HCT116 cell survival but had variable effects at enhancing tumor cell radiosensitivity. 15713897 2005