Disease: Tumor Cell Invasion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE The aim of the current study was to investigate the effect of si-PDK1 on the RCC cell apoptosis, proliferation, migration, invasion and epithelial mesenchymal transition (EMT) in connection with the PI3K-PDK1-Akt pathway. 30465826 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 AlteredExpression phenotype BEFREE However, administration of PDTC reversed the effects of overexpression of PDK-1 on cell migration and invasion. 28109078 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE The aim of this review is to summarize the various mechanisms by which PDK1 controls the cell migration process, from cell polarization to actin cytoskeleton and focal adhesion regulation, and finally, to discuss the evidence supporting a role for PDK1 in cancer cell invasion and dissemination. 28287465 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 AlteredExpression phenotype BEFREE As predicted, interference of PDK1 showed the similar effects to miR-138-1* in the proliferation, colony formation, migration and invasion of P50 B-2A13 cells. 26084420 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is centrally involved in cancer progression, including proliferation, apoptosis and invasion. 26055151 2015
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 AlteredExpression phenotype BEFREE After that, we performed migration and invasion assays of siRNA-targeted PDK1-transfected cells in vitro. 25416048 2014
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE We further show that this novel PDK1-PLCγ1 pathway is important for cancer cell invasion. 22454520 2012