|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
3-phosphoinositide dependent protein kinase-1 (PDK1), a transducer protein that functions downstream of PI3K, is responsible for the regulation of cell proliferation and migration and it also has been found to play a key role in different cancers, pancreatic and breast cancer amongst others.
|
31683659 |
2019 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
3-phosphoinositide dependent protein kinase-1 (PDK1), a transducer protein that functions downstream of PI3K, is responsible for the regulation of cell proliferation and migration and it also has been found to play a key role in different cancers, pancreatic and breast cancer amongst others.
|
31683659 |
2019 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
CTD_human |
Our data implicate PDK-1 and downstream components of the PDK-1 signaling pathway as promising therapeutic targets for the treatment of breast cancer.
|
24739482 |
2014 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
Our data implicate PDK-1 and downstream components of the PDK-1 signaling pathway as promising therapeutic targets for the treatment of breast cancer.
|
24739482 |
2014 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
CTD_human |
Our data implicate PDK-1 and downstream components of the PDK-1 signaling pathway as promising therapeutic targets for the treatment of breast cancer.
|
24739482 |
2014 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
Our data implicate PDK-1 and downstream components of the PDK-1 signaling pathway as promising therapeutic targets for the treatment of breast cancer.
|
24739482 |
2014 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
In summary, these results suggest that PDK1 may contribute to breast cancer, even in the absence of PI3K oncogenic mutations and through both Akt-dependent and Akt-independent mechanisms.
|
22952425 |
2012 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
In summary, these results suggest that PDK1 may contribute to breast cancer, even in the absence of PI3K oncogenic mutations and through both Akt-dependent and Akt-independent mechanisms.
|
22952425 |
2012 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
In severe combined immunodeficiency mice, PDK1-depleted human breast cancer cells formed more slowly growing tumors and were defective in extravasation to mouse lungs after i.v. injection.
|
19531564 |
2009 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
In severe combined immunodeficiency mice, PDK1-depleted human breast cancer cells formed more slowly growing tumors and were defective in extravasation to mouse lungs after i.v. injection.
|
19531564 |
2009 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
The phosphorylation of FAK, mTOR, p70S6K, and PDK-1 were elevated in both breast cancer cell lines, whereas the phosphorylation of AKT, EGFR, ErbB2/Her2, PDGFR, Shc, and Stat3 were elevated in only one breast cancer line compared to normal primary mammary epithelial cells and telomerase-immortalised breast epithelial cells.
|
16288304 |
2005 |
|
Breast Carcinoma
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Consistent findings were obtained as greater than 70% of invasive breast carcinomas expressed moderate to high levels of phosphorylated PDK-1, AKT, p70S6K, and EGFR.
|
16288304 |
2005 |
|
Malignant neoplasm of breast
|
0.550 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.550 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Diffuse Large B-Cell Lymphoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show for the first time that 3-phosphoinositide-dependent protein kinase 1 (PDPK1), an oncogenic serine-threonine protein kinase, is commonly expressed in its phosphorylated active form in patient-derived tumor cells of various types of B-cell NHL cells, including diffuse large B-cell lymphoma, follicular lymphoma, and MCL.
|
29287939 |
2018 |
|
Mammary Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Immunohistochemical analysis of PDK1 expression in breast cancer.
|
24739482 |
2014 |
|
Diffuse Large B-Cell Lymphoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.
|
21173233 |
2011 |
|
Mammary Neoplasms
|
0.310 |
PosttranslationalModification
|
group |
BEFREE |
Particularly, moderate to high level of PDK-1 phosphorylation was found in 86% of high-grade metastasised breast tumours.
|
16288304 |
2005 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Immunohistochemical analysis of PDK1 expression in breast cancer.
|
24739482 |
2014 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Immunohistochemical analysis of PDK1 expression in breast cancer.
|
24739482 |
2014 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
|
19429709 |
2009 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
|
19429709 |
2009 |
|
Left-Sided Heart Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
|
19429709 |
2009 |
|
Heart Failure, Right-Sided
|
0.300 |
Biomarker
|
disease |
CTD_human |
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
|
19429709 |
2009 |
|
Myocardial Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
|
19429709 |
2009 |