PDYN, prodynorphin, 5173

N. diseases: 197; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease PSYGENET Fifteen percent (n=151) of the sample met DSM-IV criteria for alcohol dependence and while results did not support an association between the PDYN polymorphism and the diagnosis of alcohol dependence, we did observe an association between the "low" expressing L allele of the PDYN gene and a preference for engaging in disinhibited behavior. 21736916 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain. 21338584 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease BEFREE Three PDYN CpG-SNPs associated with alcoholism were found to be differently methylated in the human brain. 21521424 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Fifteen percent (n=151) of the sample met DSM-IV criteria for alcohol dependence and while results did not support an association between the PDYN polymorphism and the diagnosis of alcohol dependence, we did observe an association between the "low" expressing L allele of the PDYN gene and a preference for engaging in disinhibited behavior. 21736916 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease CTD_human A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. 18923396 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease CTD_human Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence. 17559549 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Thus, variations in the genes encoding both the kappa-opioid receptor and its ligand, OPRK1 and PDYN, are associated with the risk for alcohol dependence; this makes biological sense as variations in either should affect signaling through the kappa-opioid system. 16924269 2006
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE The results suggest that no major influence on alcoholism is exerted through genes associated with this prodynorphin allelic marker. 9347097 1997
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease PSYGENET Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. 24816773 2014
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease PSYGENET Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction. 22443215 2012
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 GeneticVariation disease BEFREE Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction. 22443215 2012
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 GeneticVariation disease BEFREE We tested polymorphisms of the prodynorphin gene (PDYN) for association with cocaine dependence and cocaine/alcohol codependence. 18923396 2009
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease PSYGENET We tested polymorphisms of the prodynorphin gene (PDYN) for association with cocaine dependence and cocaine/alcohol codependence. 18923396 2009
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease CTD_human We tested polymorphisms of the prodynorphin gene (PDYN) for association with cocaine dependence and cocaine/alcohol codependence. 18923396 2009
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease CTD_human Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. 18575850 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease CTD_human Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence. 17559549 2007
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease CTD_human Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. 16184603 2005
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease PSYGENET Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. 16184603 2005
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 GeneticVariation disease BEFREE Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. 16184603 2005
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 Biomarker disease PSYGENET Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. 11992566 2002
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.540 GeneticVariation disease BEFREE Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. 11992566 2002
CUI: C0030193
Disease: Pain
Pain 		0.340 Biomarker phenotype BEFREE This study represents a novel nanomedicine approach, allowing the specific delivery of LENK neuropeptide into inflamed tissues for pain control. 30788432 2019
CUI: C0030193
Disease: Pain
Pain 		0.340 Biomarker phenotype BEFREE Pairwise tag single nucleotide polymorphisms (SNPs) in DREAM, PDYN and OPRK1 were genotyped in a UK population-based discovery cohort in whom pain was assessed using blank body manikins at three time points. 22730276 2013
CUI: C0030193
Disease: Pain
Pain 		0.340 Biomarker phenotype CTD_human Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli. 20068450 2010
CUI: C0030193
Disease: Pain
Pain 		0.340 GeneticVariation phenotype BEFREE Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might enhance pain relief in the periphery. 18507845 2008