PDYN, prodynorphin, 5173

N. diseases: 197; N. variants: 13
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease BEFREE The prodynorphin gene (PDYN) gives rise to dynorphin opioid peptides mediating depression and substance dependence. 28968778 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. 24816773 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET A trend for association between depression severity and PDYN variation was detected. 23101464 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging. 23904614 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation. 23293139 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. 24231353 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease BEFREE Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. 24231353 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease BEFREE A trend for association between depression severity and PDYN variation was detected. 23101464 2013