Breast Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Differential regulation of the WWOX gene plays an important role in the carcinogenesis of breast cancer, due partially to methylation of the WWOX DNA CpG islands.
|
19188760 |
2009 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The major finding of our study is the novel role of WWOX in the chemoresistance of breast cancer through the regulation of cell stemness and EMT.
|
30335523 |
2018 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Altogether, our data established that Wwox suppresses BC cell metastasis and proliferation by JAK2/STAT3 pathway.
|
30154439 |
2018 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells.
|
25678599 |
2015 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reduced WWOX expression is associated with the basal-like subtype and a poor disease-free survival rate for breast cancer patients.
|
20401669 |
2011 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recent study demonstrated that breast cancer patients exhibiting higher WWOX expression showed significantly longer disease-free survival in contrast to the group with lower relative WWOX level.
|
21347750 |
2011 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, identification of two distinct alternative WWOX transcripts expressed at high levels in human tumors suggests an involvement of the WWOX gene in breast cancer progression.
|
11896615 |
2002 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
WWOX and FHIT promoter methylation is detected in tissue adjacent to breast cancer and WWOX exon 1 MSP distinguishes breast cancer DNA from DNA of adjacent and normal tissue.
|
15674328 |
2005 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, we found a statistically significant correlation between WWOX expression and estrogen receptor (ER) status, 27% of ER+ breast carcinomas were completely negative for WWOX expression versus 46% for ER-cases (p = 0.0054).
|
15692750 |
2005 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Wwox protein expression was restored by the following: (a) infection with a recombinant adenovirus carrying WWOX cDNA (Ad-WWOX) or (b) treatment with the DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, to activate the endogenous WWOX gene, in breast cancer-derived cells in vitro and in vivo.
|
17200365 |
2007 |
Breast Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Genetic alterations of the WWOX gene in breast cancer.
|
21983861 |
2012 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The constitutive activation of nuclear Met-signaling pathway in MDA-MB231 cells, possibly determined at genetic or epigenetic levels of WWOX gene, might participate in breast carcinoma progression influencing invasive/metastatic phenotype.
|
19357348 |
2009 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
WWOX, WW domain-containing oxidoreductase, is a tumor suppressor that is altered in many human cancers, including breast cancer.
|
17909041 |
2007 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
WWOX and FHIT are two candidate tumor suppressor genes located in active fragile sites, the damage of which has been associated with the development of breast cancer.
|
19080258 |
2008 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed a mutation screening of WWOX exons in a panel of breast cancer lines, most of which are hemizygous for the 16q genomic region indicated.
|
10786676 |
2000 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our recent studies show critical functions of Wwox present in 1833-osteotropic clone, in the corresponding xenograft model, and in human bone metastasis from breast carcinoma.
|
28045433 |
2017 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The WWOX gene is down-regulated in breast cancer and loss of Wwox expression correlates with important clinical features of breast cancer.
|
17200365 |
2007 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α.
|
30285739 |
2018 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this report, we demonstrate that ectopic WWOX expression strongly inhibits anchorage-independent growth in soft agar of breast cancer cell lines MDA-MB-435 and T47D.
|
11719429 |
2001 |
Breast Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast, breast cancer development to a premetastatic state is associated with upregulation and Tyr33 phosphorylation of cytosolic WOX1 and WOX2, followed by significant downregulation or absent expression during metastasis.
|
15580310 |
2005 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since loss of WWOX expression increases with breast cancer progression and it behaves as an inhibitor of SMAD3 transcriptional activity these observations may help explain, at least in part, the paradoxical pro-tumorigenic effects of TGFβ signaling in advanced breast cancer.
|
24330518 |
2013 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Altogether, our data uncover an essential role for WWOX as a bona fide breast cancer tumor suppressor through the maintenance of p53 stability.
|
30082886 |
2018 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Metanalysis of gene expression datasets demonstrates that low WWOX expression is significantly associated with shorter relapse-free survival in ovarian and breast cancer patients.
|
24932569 |
2014 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The WW domain-containing oxidoreductase (WWOX) is commonly inactivated in multiple human cancers, including breast cancer.
|
23254778 |
2013 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Decoding the link between WWOX and p53 in aggressive breast cancer.
|
31075076 |
2019 |