Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Specific single nucleotides polymorphisms (SNPs) rs4977756 (CDKN2A/B), rs6010620 (RTEL1), rs498872 (PHLDB1), rs2736100 (TERT), and rs4295627 (CCDC26) have been associated with glioma susceptibility and are potential risk biomarkers.
|
31721021 |
2020 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
|
30714141 |
2019 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Statistical analyses on the association between RTEL1 single nucleotide polymorphisms (SNPs) and glioma risk were conducted using unconditional logistic regression.
|
30462709 |
2018 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
|
29743610 |
2018 |
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The present study focuses on the impact of MPHOSPH6, TNIP1 and several other genes (ACYP2, NAF1, TERC, TERT, OBFC1, ZNF208 and RTEL1) on telomere length and how this affects the prognosis of glioma.
|
28985021 |
2017 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thirteen well known genetic risk variants in TERT, EGFR, CCDC26, CDKN2A, CDKN2B, PHLDB1, TP53, and RTEL1 were selected for investigation of possible correlations with the glioma somatic markers: EGFR amplification, 1p/19q codeletion and protein expression of p53, Ki-67, and mutated IDH1.
|
26839018 |
2016 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The pooled results indicated that the RTEL1 rs2297440 polymorphism moderately increased the risk of glioma in all genetic models.
|
26939676 |
2016 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association with glioma risk for variants within five genomic regions: 8q24.21 (CCDC26), 9p21.3 (CDKN2B-AS1), 11q23.3 (PHLDB1), 17p13.1 (TP53), and 20q13.33 (RTEL1).
|
25713050 |
2015 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analyses by ethnicity showed that RTEL1 rs6010620 polymorphism resulted in a higher risk of glioma among both Asians and Caucasians.
|
24523019 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma.
|
25227808 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
|
24908248 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
|
24908248 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The A allele of rs6010620 in RTEL1 decreased the risk of developing glioma in the 12 case-control studies for all genetic models: the allele model (OR=0.752, 95%CI: 0.715-0.792), the dominant model (OR=0.729, 95%CI: 0.685-0.776), the recessive model (OR=0.647, 95%CI: 0.569-0.734), the homozygote comparison (OR=0.528, 95%CI: 0.456-0.612), and the heterozygote comparison (OR=0.761, 95%CI: 0.713-0.812).
|
25556444 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1).
|
23161787 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
And it might be used to evaluate the glioma development risks to screen the above RTEL1 tagging SNPs and haplotypes.
|
23683922 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in or near RTEL1 and TERT, key components of telomere biology, are associated with glioma risk.
|
24231251 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, as previously shown for glioma regardless of family history of brain tumours, rs6010620 (RTEL1) was associated with an increased risk of glioma when restricting to cases with family history of brain tumours.
|
23115063 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have implicated single nucleotide polymorphisms (SNPs) in 7 genes as glioma risk factors, including 2 (TERT, RTEL1) involved in telomerase structure/function.
|
23733245 |
2013 |
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Eight SNPs in/near seven different genes (TERT, EGFR, CCDC26, CDKN2A, PHLDB1, RTEL1, TP53) were significantly associated with glioma risk in the combined dataset (P < 0.05), with all associations in the same direction as in previous reports.
|
23280628 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of glioma and meta-analysis.
|
22886559 |
2012 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of glioma and meta-analysis.
|
22886559 |
2012 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among 99 SNPs, five independent susceptibility loci (20-62315594 in RTEL1, 20-62335293 in adenosine diphosphate ribosylation factor-related protein 1, rs3761121 in ZGPAT, rs1058319 in SLC2A4RG and rs5019252 in ZBTB46) were identified for glioma.
|
22387365 |
2012 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population.
|
21920947 |
2011 |