|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The most frequent tumour was NHL (21.1%), followed by lung carcinoma (15%).
|
31471061 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
A high incidence ratio of the event was also detected in specific primary tumor sites: hypopharynx (Observed/Expected(O/E) = 44.59); other endocrine tissue (including the thymus) (O/E=38.27); chronic myeloid leukemia (O/E=11.15); small intestine (O/E=8.86); liver (O/E=8.74); stomach (O/E=4.95); nodal NHL (O/E=3.79); kidney and renal pelvis (O/E=3.19); and breast (O/E=1.78).
|
30139816 |
2018 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Future clinical trials will be important to investigate the efficacy of targeting BCL6 in B-NHL (and other neoplasms), particularly in combination with other therapies.
|
29262721 |
2018 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The genetic risk in the telomere regulating genes TERT and RTEL appear to be associated with higher grade tumors without IDH mutations.
|
24184969 |
2013 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
We used quantitative realtime PCR to assess the expression of miRNAs from three different paralog clusters, miR-17-92, miR-106a-363, and miR-106b-25 in 24 cases of AIDS-NHLs representing four tumor types, Burkitt's lymphoma (BL, n = 6), diffuse large B-cell lymphoma (DLBCL, n = 8), primary central nervous system lymphoma (PCNSL, n = 5), and primary effusion lymphoma (PEL, n = 5).
|
21698185 |
2011 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Results showed clear heterogeneity according to histologic subtypes of glioma, with TERT and RTEL variants a feature of astrocytic tumors and glioblastoma (GBM), CCDC26 and PHLDB1 variants a feature of astrocytic and oligodendroglial tumors, and CDKN2B variants most prominent in GBM.
|
21203894 |
2011 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Follow-up information of 496 female NHL incident cases diagnosed during 1996-2000 in Connecticut were abstracted from the Connecticut Tumor Registry in 2008; survival analyses were conducted by comparing the Kaplan-Meier curves, and hazard ratios (HR) were computed from the Cox Proportional Hazard models adjusting for demographic and tumor characteristics which were suggested by previous studies to be determinants of NHL survival.
|
20029944 |
2010 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Our findings of higher DNA concentrations with some p53 mutations in CFDNA from patients with NHL that match the previous reported p53 mutations from tumour DNA may hold promises that CFDNA may serve as a convenient source of tumour-derived DNA to serve as a promising tool of a non-invasive, low-cost new strategy for earlier detection, diagnosis and follow up of the disease.
|
19046801 |
2009 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Fifty acute T-cell lymphoblastic leukemia (T-ALL) samples and 33 samples from patients with various rare mature T-cell neoplasms (T-PLL, Sézary syndrome and other T-NHL) were subsequently investigated.
|
17284327 |
2007 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Rearrangements involving the 1p36 chromosomal region occur frequently in NHL, suggesting the existence of tumor suppressor gene(s) that are important in lymphomagenesis. p73 is closely related to the tumor suppressor p53 and maps to the chromosome 1p36 region.
|
15475076 |
2004 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
We analyzed AIDS-related S-NHL samples, NHL samples from HIV-negative patients, peripheral blood leukocytes from HIV-infected and -uninfected patients without NHL, and lymph nodes without tumors from HIV-infected patients.
|
11832678 |
2002 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
We analysed CLL as well as low and high grade B-cell NHL for expression of G1-specific and universal CKI by competitive RT-PCR and immunostaining. p16(INK4A) expression was low in all types of neoplasms.
|
11042528 |
2000 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
These results show that EBV infection of the tumor clone significantly increases the risk of CNS involvement by systemic AIDS-NHL, without regard of specific molecular features.
|
11013271 |
2000 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
We conclude that deletions of the analyzed tumor suppressor genes are relatively rare in MZBCL, which contrasts with the findings in some other subtypes of NHL.
|
10913669 |
2000 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Certain classes of AIDS NHL are associated with alterations in oncogenes or tumor-suppressor genes or infections by oncogenic herpesviruses.
|
10449776 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The most interesting finding, however, was a striking tendency of blastoid MCL subtypes to harbour chromosome numbers in the tetraploid range, a feature clearly separating these neoplasms from other types of B-cell NHL and possibly being related to its unphysiological expression of cyclin D1.
|
10037001 |
1998 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Taken together, these data suggest that concurrent overexpression of cyclin D1 and functional elimination of p16CDKN2 and p15CDKN2B may characterize certain cases of mantle cell NHL, and that cooperation of the abnormalities is likely to provide a growth advantage of the tumour cells through more efficient inactivation of the RB tumor suppressor.
|
9001420 |
1997 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The data presented here indicate that the pathogenesis of AIDS-NHL is variably associated with multiple genetic alterations including monoclonal EBV infection, oncogene activation (c-myc, N-, Ki-ras) and tumor suppressor gene (p53) inactivation.
|
1325169 |
1992 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
TcR gene rearrangements were observed in lymphocytic, lymphoblastic and immunoblastic lymphoma, however, in the remaining 14 phenotypically and histologically defined peripheral T-cell lymphomas, 2 showed rearrangement of TcR gamma and beta genes consistent with T NHL and 2 showed Ig JH rearrangements only, suggestive of either reactive T-cell populations masking cryptic disease or presence of tumour populations with aberrant gene rearrangement and expression of T lineage antigens.
|
2852027 |
1988 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
HPO |
|
|
|