SERPINF1, serpin family F member 1, 5176

N. diseases: 294; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE Whether PEDF is increased or decreased in diabetic retinopathy has been controversial but we observed lower PEDF in the ROP samples than in the controls. 28502635 2017
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 AlteredExpression disease BEFREE Furthermore, we pursue the causal relationship between LOX-NOX system and regulation of PEDF expression during DR. For these purposes, we used an experimental eye model in which normal mice were injected intravitreally with 12-HETE with/without PEDF. 25562624 2015
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 AlteredExpression disease BEFREE These results demonstrate long-term efficacy of AAV-mediated PEDF overexpression in counteracting retinal neovascularization in a relevant animal model, and provides evidence towards the use of this strategy to treat angiogenesis in DR and other chronic proliferative retinal disorders. 22911805 2012
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE These results suggest that PEDF is an endogenous antagonist of LRP6, and blocking Wnt signaling may represent a novel mechanism for its protective effects against diabetic retinopathy. 21576363 2011
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE The PEDF-Tg mice provide a useful model for studying the roles of angiogenic inhibitors in neovascular disorders such as diabetic retinopathy. 21281801 2011
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 AlteredExpression disease BEFREE Antiangiogenic effects and transcriptional regulation of pigment epithelium-derived factor in diabetic retinopathy. 20219495 2010
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 GeneticVariation disease BEFREE Our results suggest lack of association of PRKCB1 gene promoter polymorphisms and moderate protective association of PEDF gene polymorphism with DR in the south Indian population. 20141354 2010
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 GeneticVariation disease BEFREE In addition, two other PEDF gene polymorphisms, -5736T>C (rs12150053) and -5304C>T (rs12948385), have been associated with increased risk of diabetic retinopathy, but have not yet been studied among patients with exudative AMD. 19223990 2009
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 AlteredExpression disease LHGDN The mean plasma PEDF level in patients with PDR (7.69+/-6.14 microg/ml; mean+/-standard error) was significantly higher than that of mild-to-moderate nonproliferative diabetic retinopathy (5.07+/-4.37 microg/ml, p=0.02). 18523656 2008
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE PEDF was determined in surgically excised retinal tissue originating from patients with ischemic diabetic retinopathy and in primary guinea pig Müller cell cultures exposed to the protein synthesis inhibitor cycloheximide (CHX) and to hypoxia. 18676622 2008
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE These results demonstrate that the PEDF gene, in cooperation with the VEGF gene, may contribute to the development of DR. 17658465 2007
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease LHGDN However, a role for PEDF in early diabetic retinopathy remains to be elucidated. 16797605 2007
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 AlteredExpression disease LHGDN The plasma level of PEDF was measured by ELISA, and the stage of diabetic retinopathy was determined by ophthalmic examinations. 17213275 2007
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease LHGDN These results demonstrate that the PEDF gene, in cooperation with the VEGF gene, may contribute to the development of DR. 17658465 2007
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE Recently, pigment-epithelium-derived factor (PEDF) has also been shown to play a role in diabetic retinopathy. 17284935 2007
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. 17653050 2007
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. 16901919 2006
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease RGD The high levels of PEDF in the retina of SDT rats may contribute to the low incidence of neovascular formation and absence of non-perfused areas that do not match the typical diabetic retinopathy in humans. 16054135 2006
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE Substitution of PEDF may offer a promising strategy for halting the development of diabetic retinopathy. 16707486 2006
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.300 Biomarker disease BEFREE Since sympathetic nerves are damaged in diabetes and PEDF appears to be regulated by beta-adrenergic receptors, these results suggest a role for sympathetic nerves in diabetic retinopathy. 15961351 2005