|
Obesity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Correspondingly, the PEDF-knockout mice exhibited lipid metabolism disorder and insulin resistance, which mainly manifested as obesity, abdominal fat accumulation, adipocyte enlargement, severe ectopic fat deposition, dyslipidemia, changes in adipokine levels, hyperglycemia, hyperinsulinemia, impaired glucose tolerance, impaired insulin tolerance and significantly declined protein kinase B (Akt) phosphorylation levels.
|
30414426 |
2019 |
|
Obesity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice.
|
31121128 |
2019 |
|
Obesity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Chemerin and PEDF Are Metaflammation-Related Biomarkers of Disease Activity and Obesity in Rheumatoid Arthritis.
|
30123797 |
2018 |
|
Obesity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Pigment epithelium-derived factor (PEDF) is associated with obesity and diabetes complications in adults, yet little is known about PEDF in younger individuals.
|
28399539 |
2017 |
|
Obesity
|
0.290 |
Biomarker
|
disease |
RGD |
In vivo, the high-fat group showed increased serum PEDF levels, which negatively correlated with insulin sensitivity, whereas the rosiglitazone treatment decreased the serum PEDF and down-regulated PEDF expression in fat and liver of the obese rats, concomitant with significantly enhanced insulin sensitivity.
|
24424059 |
2014 |
|
Obesity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Experiments conducted in mice rendered obese by high-fat feeding showed no differences between PEDF-aP2 and wild-type mice for body mass, adiposity, whole body energy expenditure, glucose tolerance, or adipose tissue oxygenation.
|
24760990 |
2014 |
|
Obesity
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
However, OM PEDF relative gene expression was decreased in morbidly obese subjects (P=0.01).
|
23318725 |
2013 |
|
Obesity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Genetic association studies in older, mostly non-Hispanic populations have reported that polymorphisms in the candidate genes HSD11B1, CRP, ADIPOQ, PPARG, ANKK1, ABCC8 and SERPINF1 are associated with obesity or diabetes.
|
22056417 |
2011 |
|
Obesity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Differences in PEDF observed after weight loss were related to changes in obesity, insulin resistance, and blood pressure measures.
|
20631025 |
2010 |
|
Obesity
|
0.290 |
Biomarker
|
disease |
BEFREE |
In the present study, we determined the relationship between plasma concentration of a recently identified adipokine, pigment epithelium-derived factor (SERPINF1), and human obesity, particularly specific adipose tissue depots, and other features of the metabolic syndrome.
|
18787046 |
2008 |