|
Retinopathy of Prematurity
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Astragalus root extract was also found to decrease VEGF and HIF-1α expression, but enhance PEDF and IGF-1 expression in the OIR model mice, thereby protecting retinas in ROP.
|
31564208 |
2019 |
|
Retinopathy of Prematurity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Whether PEDF is increased or decreased in diabetic retinopathy has been controversial but we observed lower PEDF in the ROP samples than in the controls.
|
28502635 |
2017 |
|
Retinopathy of Prematurity
|
0.290 |
Biomarker
|
disease |
RGD |
Mean VEGF and PEDF protein levels were determined at different ages for rats in the ROP model and for RA-raised rats, and the ratio of VEGF/PEDF protein versus age was plotted.
|
21738387 |
2011 |
|
Retinopathy of Prematurity
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Prevention of premature retinopathy by SkQ1 was connected with an increase of VEGF mRNA and protein in OXYS rat's retina up to the levels corresponding to the Wistar rats, and did not involve changes in PEDF expression.
|
21750722 |
2011 |
|
Retinopathy of Prematurity
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Mean VEGF and PEDF protein levels were determined at different ages for rats in the ROP model and for RA-raised rats, and the ratio of VEGF/PEDF protein versus age was plotted.
|
21738387 |
2011 |
|
Retinopathy of Prematurity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Retinas isolated from a 50/10 oxygen (inspired oxygen cycled between 50% oxygen and 10% oxygen every 24 hours)-induced rat model of retinopathy of prematurity (50/10 OIR model), and from room air-raised rat pups (RA) at birth, age 14 days (persistent peripheral avascular retina in the 50/10 OIR model and complete retinal vascularization in RA) and age 18 days (intravitreous neovascularization in the 50/10 OIR model) were analyzed for messenger RNA of VEGF(164), neuropilin 1, neuropilin 2, VEGF receptor 1, VEGF receptor 2, pigment epithelium-derived factor, and pigment epithelium-derived factor receptor by real-time polymerase chain reaction.
|
20457980 |
2010 |
|
Retinopathy of Prematurity
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Levels of PEDF in RPE/choroid significantly decreased in the ROP model.
|
16043845 |
2005 |
|
Retinopathy of Prematurity
|
0.290 |
Biomarker
|
disease |
BEFREE |
Potential medical therapies for ROP, including modulators of angiogenic factors, inhibitors of basement membrane changes, endogenous inhibitors such as pigment epithelium derived factor, and anti-inflammatory drugs, have shown efficacy against neovascularization in several animal models.
|
12930159 |
2003 |
|
Retinopathy of Prematurity
|
0.290 |
Biomarker
|
disease |
BEFREE |
We used an AAV vector with rapid onset and high levels of gene expression in the retina to deliver three anti-angiogenic factors (pigment epithelium-derived factor, tissue inhibitor of metalloproteinase-3, and endostatin) to the eyes of mice in a mouse model of retinopathy of prematurity.
|
12377190 |
2002 |
|
Retinopathy of Prematurity
|
0.290 |
Biomarker
|
disease |
BEFREE |
In three murine disease models (the laser-induced choroidal neovascularization model, the VEGF transgenic model, and the retinopathy of prematurity model) significant inhibition of neovascularization (up to 85%) was demonstrated with doses of Ad(GV)PEDF vectors ranging from 1 x 10(8) to 1 x 10(9) pu.
|
11727737 |
2001 |