|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our results indicate that PEDF expression has a significant impact on oxidative and inflammatory properties of ChECs, whose alteration could contribute to pathogenesis of chronic inflammatory diseases including exudative AMD.
|
29351407 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The goal of the present study was the development of an efficient and safe technique to integrate, ex vivo, the PEDF gene into retinal pigment epithelial (RPE) cells for later transplantation to the subretinal space of AMD patients to allow continuous PEDF secretion in the vicinity of the affected macula.
|
29858090 |
2018 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T-C haplotype frequency of rs1136287-rs1894286 in PEDF were significantly correlated to the increased susceptibility to AMD (OR = 1.57, 95% CI = 1.02-2.40).The rs1136287 polymorphism in PEDF may be related to the occurrence risk of AMD.
|
30142832 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proliferative diabetic retinopathy is the most intensively studied stage of DR. Proteomic studies have established VEGF, pigment epithelium-derived factor (PEDF) and complement components as key factors associated with AMD.
|
28452939 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we will discuss the important role of thrombospondins and pigment epithelium-derived factor, two major endogenous inhibitors of angiogenesis, in retinal and choroidal vascular homeostasis and their potential alterations during AMD and choroidal neovascularization (CNV).
|
28679845 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the wet form of age-related macular degeneration is characterized by choroidal neovascularization (CNV), PEDF would be an ideal candidate to inhibit CNV and support retinal pigment epithelial (RPE) cells.
|
26697494 |
2015 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four PEDF polymorphisms were meta-analyzed: rs1136287, rs12150053, rs12948385 and rs9913583, but none was significantly associated with AMD or PCV.
|
25820866 |
2015 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further studies of comprehensive PEDF gene variations are required to characterize the susceptibility of PEDF gene in the pathogenesis of AMD.
|
21174599 |
2011 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and response to treatment with photodynamic therapy (PDT) for age-related macular degeneration (AMD) in a Japanese population.
|
20678803 |
2011 |
|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we showed that retinopathy in OXYS rats is similar to human AMD according to clinical signs, morphology, and vascular endothelium growth factor (VEGF) and pigment epithelium-derived factor (PEDF) genes expression.
|
21191149 |
2011 |
|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VEGF protein expression was increased and PEDF protein expression was decreased in RPE from smoker patients with AMD versus controls resulting in increased VEGF/PEDF ratio.
|
21386905 |
2011 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data demonstrate that brief subretinal administration of SeV-F/HN-SIV vectors may facilitate safe and efficient retinal gene transfer, and suggest the therapeutic potential of PEDF with a higher safety profile for treating CNV in AMD patients.
|
19778186 |
2010 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
PEDF genotype and allele frequencies were not significantly different between AMD patients and control subjects.
|
19223990 |
2009 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to validate the previously reported association of the PEDF Met72Thr variant in a well characterized Japanese population with neovascular AMD and PCV.
|
19503741 |
2009 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
PEDF may play a role in the pathogenesis of wet AMD.
|
18226801 |
2008 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since it is well known that a single nucleotide polymorphism and resultant amino acid change often alters the activity or expression level of the target protein, we would like to propose here a novel hypothesis that the Met72Thr polymorphism (T/C polymorphism) of PEDF gene may be a genetic marker for ARMD.
|
15823717 |
2005 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The primary objectives of this investigation are: (1) to assess the safety, tolerability and feasibility of intravitreal injection of Ad(GV)PEDF.11D in patients with severe, neovascular AMD, (2) to identify the maximum tolerated dose (MTD) of Ad(GV)PEDF.11D, and (3) to get some indication of potential activity of Ad(GV)PEDF.11D.
|
11727737 |
2001 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF.
|
11748590 |
2001 |