|
Thymic Dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that the Foxn1:CFP-NTR transgenic mouse strain represents a suitable animal model to optimize established clinical protocols, such as thymus transplantation, to correct various forms of thymic dysplasia and to explore novel treatment options.
|
28992076 |
2017 |
|
Tuberculosis, extrapulmonary
|
0.020 |
Biomarker
|
disease |
BEFREE |
We compared several gene targets of Mycobacterium tuberculosis, including IS6110, devR, and genes encoding MPB-64 (mpb64), 38kDa (pstS1), 65kDa (hsp65), 30kDa (fbpB), ESAT-6 (esat6), and CFP-10 (cfp10) proteins, using PCR assays on 105 EPTB specimens.
|
26632387 |
2016 |
|
Liver regeneration disorder
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We ablated the hepatocytes of <i>Tg(fabp10a:CFP-NTR)</i> larvae and blocked Notch activation during liver regeneration through treatment with <i>γ</i>-secretase inhibitor LY411575 and demonstrated enhanced induction of Hnf4a in LPCs.
|
30992706 |
2019 |
|
Impaired cognition
|
0.060 |
Biomarker
|
disease |
BEFREE |
Unfortunately, a major limiting factor in the development of treatments for PFC cognitive dysfunction is our limited understanding of the neural mechanisms underlying PFC-dependent cognition.
|
30651328 |
2019 |
|
Major Depressive Disorder
|
0.060 |
Biomarker
|
disease |
BEFREE |
TR and rCMRglu positively correlate in bilateral dorsomedial PFC, dlPFC, dorsal anterior cingulate; negatively correlate in bilateral MTC/subcortical regions, and cerebellum. rCMRglu in dlPFC correlates negatively with that in amygdala in HC but not in MDD.
|
30580237 |
2019 |
|
Parkinson Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
To fill this gap, we used an assay based on FRET that exploits a HEK293T "biosensor" cell line stably expressing α-syn (A53T)-CFP/YFP fusion proteins to detect α-syn seeds in brain extracts from PD and MSA patients.
|
30478174 |
2019 |
|
Post-Traumatic Stress Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
To examine directed (effective) connectivity among these nodes, as well as group differences, we conducted resting-state stochastic dynamic causal modeling (sDCM) pairwise analyses of coupling between the ventromedial (vm)PFC, the bilateral basolateral and centromedial (CMA) amygdala complexes, and the PAG, in 155 participants (PTSD [n = 62]; PTSD + DS [n = 41]; age-matched healthy trauma-unexposed controls [n = 52]).
|
28836726 |
2017 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, as for IGRA assays such as Quantiferon and T-Spot TB tests, ESAT-6 and CFP-10 are unable to distinguish LTBI from active TB when IL-2 is measured.
|
29856871 |
2018 |
|
Age related macular degeneration
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Thus, CFP does not seem to confer any risk for AMD.
|
20122735 |
2010 |
|
Meningococcal Infections
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Three properdin deficiency phenotypes have been reported--complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin protein (type III)--all associated with increased susceptibility to meningococcal disease.
|
9710744 |
1998 |
|
Schizophrenia
|
0.090 |
Biomarker
|
disease |
BEFREE |
This study used a rat model to test whether prenatal immune activation with lipopolysaccharide (LPS; at gestation days, GD, 15 and 16) or maternal iron deficiency (from GD2 to postnatal day P7) or the combination of both insults alters major subtypes of GABAergic interneurons (parvalbumin, somatostatin, cholecystokinin) in brain regions relevant to schizophrenia (medial and dorsolateral prefrontal cortex [PFC], hippocampal CA1 and dentate gyrus, ventral subiculum) in offspring at P14 or P28.
|
28214898 |
2016 |
|
Iron deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study used a rat model to test whether prenatal immune activation with lipopolysaccharide (LPS; at gestation days, GD, 15 and 16) or maternal iron deficiency (from GD2 to postnatal day P7) or the combination of both insults alters major subtypes of GABAergic interneurons (parvalbumin, somatostatin, cholecystokinin) in brain regions relevant to schizophrenia (medial and dorsolateral prefrontal cortex [PFC], hippocampal CA1 and dentate gyrus, ventral subiculum) in offspring at P14 or P28.
|
28214898 |
2016 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study confirms the high conservation for ESAT-6, CFP-10 and EspC in local M. bovis field isolates and reinforce the use of these three antigens in the diagnosis of bovine tuberculosis.
|
30029900 |
2018 |
|
Impaired cognition
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
This research indicates considerable similarity in the left PFC dysfunction and its association with cognitive deficits between the disorders.
|
30316555 |
2019 |
|
Cognition Disorders
|
0.050 |
GeneticVariation
|
group |
BEFREE |
This research indicates considerable similarity in the left PFC dysfunction and its association with cognitive deficits between the disorders.
|
30316555 |
2019 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This method exhibits great application potential in the field of nanomedical science for highly reliable point-of-care detection of CFP-10 antigen in real samples to early diagnosis of tuberculosis.
|
30205244 |
2018 |
|
Cognition Disorders
|
0.050 |
Biomarker
|
group |
BEFREE |
This changing role of ACh modulation across association cortices may help to illuminate the particular susceptibility of PFC in cognitive disorders, and provide therapeutic targets to strengthen cognition.
|
30210306 |
2018 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that serum CFP-10 quantitation holds great promise for the rapid diagnosis of suspected TB cases in patients who are HIV-infected.
|
29089034 |
2017 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results show that mixtures of synthetic overlapping peptides have potency equivalent to that of whole ESAT-6 and CFP-10 for sensitive and specific detection of infection with M. tuberculosis, and peptides have the advantage of faster production at lower cost.
|
10816479 |
2000 |
|
Schizophrenia
|
0.090 |
Biomarker
|
disease |
BEFREE |
These findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the HPC and PFC.
|
30318409 |
2018 |
|
Impaired cognition
|
0.060 |
Biomarker
|
disease |
BEFREE |
These findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the HPC and PFC.
|
30318409 |
2018 |
|
Cognition Disorders
|
0.050 |
Biomarker
|
group |
BEFREE |
These findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the HPC and PFC.
|
30318409 |
2018 |
|
Respiratory Distress Syndrome, Adult
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicated that PFD can down-regulate NLRP3 inflammasome activation and that it may offer a promising therapeutic approach for ARDS patients.
|
29783158 |
2018 |
|
Major Depressive Disorder
|
0.060 |
Biomarker
|
disease |
BEFREE |
These exploratory results support the hypothesis that MDD is a systems level disorder affecting multiple brain networks located in the PFC and provide new insights into the pathophysiology of this disorder.
|
28944772 |
2018 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These data define PFD or PFD-related agents as promising agents for human cancers associated with enhanced TGF-beta activity.
|
17234158 |
2007 |