Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Neurofibromatosis type 2 gene mutation and progesterone receptor messenger RNA expression in the pathogenesis of sporadic orbitocranial meningioma.
|
31024808 |
2019 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Development of predictive markers of recurrences may also identify high-risk patients, including proliferative markers and expression of the progesterone receptor in meningiomas, and lead to less aggressive surgery.
|
30779850 |
2019 |
Meningioma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy.
|
19731987 |
2010 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Eighty-two specimens of human meningiomas were obtained for immunohistochemical analysis with anti-GnRH, anti-GnRH-R, anti-PR, anti-ER, and anti-Ki-67 (MIB-1) antibodies, and for RT-PCR analysis of the mRNA expressions of GnRH and GnRH-R. Correlations of GnRH and GnRH-R with PR, ER, Ki-67, and clinical features such as age, sex, tumor grade, and tumor histology were assessed.
|
18980792 |
2009 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The majority of MM and FM samples were strongly positive for LHRH-R expression and PR expression.
|
24100643 |
2013 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have investigated the presence of both ER and PgR in a series of 20 human meningiomas, spanning the main histological groups, using reverse transcription linked PCR (RT-PCR).
|
9311583 |
1997 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Meningiomas are more common in females and 70-80% express the progesterone receptor, raising the possibility that high-dose exogenous estrogen/progesterone exposure, such as occurs during fertility treatments, may increase the risk of developing a meningioma.
|
30868355 |
2019 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Within the confines of this study, it is concluded that: 1) the estrogen receptor is generally absent in meningioma tissue, and 2) the progesterone receptor is mainly absent in the nuclear compartment, leading to the conclusion that the cytosolic progesterone receptor may be an inactive form.
|
2213164 |
1990 |
Meningioma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Sphenoid wing meningioma progression after placement of a subcutaneous progesterone agonist contraceptive implant.
|
8008172 |
1994 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the clinical samples of meningioma, the levels of cathepsins B and L, stefin B, and cystatin C were highest in the tumors of higher histological grades, whereas stefin A and progesterone receptor were the only markers that were significantly increased and decreased, respectively, in WHO Grade III lesions.
|
19747051 |
2010 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is therefore concluded that ERDelta5 mRNA does not play the dominant role in PR synthesis in meningioma tissue.
|
10704905 |
1999 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
EGF-R was present in almost half and progesterone receptor in most of the meningiomas.
|
7754837 |
1994 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study aims to determine the status of GnRH and GnRH-R and to elucidate the correlations of GnRH and GnRH-R with PR, ER, and clinical features in meningiomas.
|
18980792 |
2009 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Histological diagnosis confirmed a strong progesterone receptor-positive and slight estrogen positive meningioma.
|
29105524 |
2018 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Progesterone receptor (PR) expression and mifepristone treatment was highly discussed for meningiomas.
|
29453736 |
2019 |
Meningioma
|
0.400 |
Biomarker
|
disease |
CTD_human |
In the clinical samples of meningioma, the levels of cathepsins B and L, stefin B, and cystatin C were highest in the tumors of higher histological grades, whereas stefin A and progesterone receptor were the only markers that were significantly increased and decreased, respectively, in WHO Grade III lesions.
|
19747051 |
2010 |
Meningioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Significant association between lower expression of PR (OR 11.7; 95% CI 4.17-32.9; <i>P</i> < 0.001 comparing the lowest quartile vs. 3 highest quartile of PR) and <i>NF2</i> (OR 4.23; 95% CI 1.85-9.67; <i>P</i> = 0.001 comparing the 2 lowest quartiles vs. 2 highest quartiles) with increased risk of meningioma were also reported.
|
30687635 |
2018 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An increase in transcription was observed with the addition of promegestone (R5020), a progesterone agonist, only in meningioma cell cultures that were expressing the progesterone receptor.
|
8587697 |
1995 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, all grade I meningiomas with a low Ki-67 expression and a positive PR expression did not have the same metabolomic profile.
|
31679342 |
2020 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined immunohistochemically the expression of MUC4, progesterone receptor (PgR) and somatostatin receptor 2A (SSTR2A) in 140 meningiomas of various histological subtypes and 123 other mesenchymal tumours, including intracranial or sinonasal tumours and peripheral nerve sheath tumours.
|
30112770 |
2019 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
As the Ki-67 index and WHO grade were not different between these locations, the high rate of positive PGR may be responsible for the benign biology of skull base meningiomas.
|
30031954 |
2018 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The authors have demonstrated the expression of androgen and progesterone receptor messenger ribonucleic acid and protein product in nine primary human meningiomas by Northern blot analysis.
|
8433149 |
1993 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Evaluation of 1p and 14q status, MIB-1 labeling index and progesterone receptor immunoexpression in meningiomas: Adjuncts to histopathological grading and predictors of aggressive behavior.
|
25237942 |
2014 |
Meningioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The medical records from 366 patients treated for meningiomas from 2003 to 2016 were retrospectively analyzed for age, gender, anatomical localization, recurrence-free survival, overall survival, histopathological diagnosis, and immunohistochemistry findings for 6 markers: epithelial membrane antigen (EMA), progesterone receptor (PR), CD34, S100, p53, and Ki-67 labeling index.
|
30503291 |
2019 |
Meningioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Sixty-four % of the meningiomas expressed progesterone receptor mRNA.
|
8443810 |
1993 |