Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic evolution of breast cancer: II. Relationship with estrogen and progesterone receptor expression.
|
1391976 |
1992 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is fairly well accepted that the presence of estrogen receptor (ER) and progesterone receptor (PgR) identifies breast cancer patients with a lower risk of relapse and better overall survival.
|
1728420 |
1992 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since progesterone receptor (PgR) is normally induced by estrogen, breast cancer lacking estrogen receptor (ER) would also be expected to lack PgR.
|
1988075 |
1991 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By performing both hormone- and DNA-binding assays of ER and the hormone-binding assay of progesterone receptor (PR), we found the following subgroups of breast cancer: (a) E2+/ERE+/PR+, (b) E2+/ERE+/PR-, (c) E2+/ERE-/PR+, (d) E2+/ERE-/PR-, (e) E2-/ERE+/PR+, (f) E2-/ERE+/PR-, (g) E2-/ERE-/PR-.
|
2054780 |
1991 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Epidermal growth factor gene expression in human breast cancer biopsy samples: relationship to estrogen and progesterone receptor gene expression.
|
2364377 |
1990 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor regulation by retinoic acid in the human breast cancer cell line T-47D.
|
2373707 |
1990 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor-containing T47D human breast cancer cells are responsive to progestins but fail to respond to other steroid hormones, in particular dexamethasone, because they have no measurable levels of receptors for estrogens, androgens, or glucocorticoids.
|
2550815 |
1989 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Sixteen human breast carcinomas were subjected to molecular biological and biochemical analyses to determine tumor cell MDR-1 (P-glycoprotein) levels and progesterone receptor content.
|
2576982 |
1989 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The human breast cancer cell line MCF-7 responds to estrogens with increased progesterone receptor (PR) levels.
|
3342760 |
1988 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
PR mRNA species are not detected in the PR protein-negative breast cancer cell lines MDA-MB-231 and LY2.
|
3398853 |
1988 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A lambda gt10 library containing DNAs complementary to messenger RNAs from human breast cancer T47-D cells was constructed and screened with a cDNA probe encoding the rabbit progesterone receptor.
|
3551956 |
1987 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Diagnosis of BC was made for all patients on surgical mastectomy specimens; histologic grading, estrogen (ER) and progesterone (PgR) receptors were determined on all primary tumors.
|
3873417 |
1985 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Under normal culturing conditions, the T47D human breast cancer cell line expresses progesterone receptor constitutively and is responsive to estrogen.
|
7499360 |
1995 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Integrated information from the quantitative analysis in tumour tissue of biological parameters such as oestrogen and progesterone receptors (ER and PGR), proliferative activity, and proto-oncogene p53, c-erB2, and bcl-2 expression, may be useful for defining the biology of growth of breast carcinoma and to plan effective therapeutic strategies.
|
7612493 |
1995 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Exon 5 deletion variant estrogen receptor messenger RNA expression in relation to tamoxifen resistance and progesterone receptor/pS2 status in human breast cancer.
|
7812959 |
1995 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists.
|
7821706 |
1994 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor size, axillary lymph nodal status, SPF-LI, nuclear size, and ER all related strongly to breast cancer specific survival and relapse free survival.PgR was less effective.
|
7922981 |
1994 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Estrogen and progesterone receptor mRNA levels in primary breast cancer: association with patient survival and other clinical and tumor features.
|
7927940 |
1994 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The biological features of tumour type, histological grade, vascular invasion, mitotic index, DNA index, and oestrogen receptor (ER) and progesterone receptor (PgR) status have been investigated as prognostic factors in primary operable breast cancer.
|
8049459 |
1994 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Relationship between loss of estrogen and progesterone receptor expression and of 6q and 11q chromosome arms in breast cancer.
|
8150542 |
1994 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to determine the frequency of p53 gene mutations in primary breast cancer, to correlate the presence of p53 mutations with established clinicopathologic parameters, including the estrogen receptor (ER) and progesterone receptor (PR) status, and to assess the prognostic significance of p53 mutations regarding patient survival.
|
8156519 |
1994 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Preferential stimulation of human progesterone receptor B expression by estrogen in T-47D human breast cancer cells.
|
8530508 |
1995 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the relative expression of PR A and B in breast cancer has not been described and its clinical significance has not been addressed.
|
8603052 |
1996 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The biologic profile of 907 infiltrating breast carcinomas was determined considering estrogen receptor (ER) and progesterone receptor (PR), proliferation index (PI) and c-erbB-2/Neu expression.
|
8625078 |
1995 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The small numbers of cases in some categories and the corresponding wide CIs preclude definitive conclusions, but these data are at least suggestive that joint stratification of breast tumors on ER and PR status may be useful in partitioning breast cancer families into more homogeneous subsets.
|
8722747 |
1996 |